Psoriasis

41 SNPs linked to Psoriasis across 12 genes, 15 with a genotype of magnitude 2 or higher.

Type: Condition
SNPs: 41
Notable: 15Magnitude 2 or higher
Well documented: 17
Genes: 12

Linked SNPs

Every genotype, as shown in 23andMe and AncestryDNA files.

rs2395029HCP5Very important
- G;GHLA-B*5701 homozygote likely if Caucasian or Hispanic; high risk for hypersensitivity to various drugs including abacavir; 2x psoriasis risk; see detailsBad
- G;THLA-B*5701 carrier most likely (if Caucasian or Hispanic)Bad
- T;TcommonGood
rs11209026IL23RImportant
- A;A0.26x lower risk for certain autoimmune diseases.Good
- A;G0.26x lower risk for certain autoimmune diseases.Good
- G;GNormal, but higher risk for certain autoimmune diseases.Bad
rs1265159POU5F1Worth knowing
- G;GnormalNot rated
- A;G~5x increased risk of psoriasisBad
- A;A22.6x increased psoriasis risk for ChineseNot rated
rs1265181Worth knowing
- G;GnormalGood
- C;Gincreased risk for psoriasisBad
- C;Cpossibly increased risk of psoriasisBad
rs1800629TNFWorth knowing
- A;Acomplex; generally higher risk for certain diseasesBad
- A;Gcomplex; generally higher risk for certain diseasesBad
- G;Gcomplex; generally normal riskGood
rs10484554LOC107984146Worth knowing
- C;CcommonGood
- C;T2.8x increased risk for psoriasisBad
- T;T~4x increased risk for psoriasisBad
rs2201841IL23RWorth knowing
- T;TNo summary available.Not rated
- G;G1.5x increased risk for Crohn's diseaseBad
- A;G1.5x increased risk for Crohn's disease; 2x increased risk for Graves' diseaseBad
- A;A2.4x increased risk for Graves' diseaseBad
rs3212227IL12BWorth knowing
- T;T1.43x increased risk of developing psoriasis and psoriatic arthritisBad
- G;TSignificantly increased risk of developing cervical cancerBad
- G;GSignificantly increased risk of developing cervical cancerBad
rs7530511IL23RWorth knowing
- C;CnormalNot rated
- C;TnormalNot rated
- T;T9x increased risk for Graves diseaseBad
rs361525TNFTypical
- A;Acomplex; generally higher risk for certain diseasesNot rated
- A;Gcomplex; generally higher risk for certain diseasesNot rated
- G;Gcomplex; generally normal riskGood
rs887466PSORS1C3Typical
- T;TNo summary available.Not rated
rs1799752ACETypical
- -;-common in clinvarGood
- T;Tcommon in clinvarGood
rs1800925TH2LCRRTypical
- C;Ccommon/normalGood
rs2066808STAT2Typical
- A;ANo summary available.Not rated
rs3213094IL12BTypical
- T;T0.79x risk for psoriasisGood
- C;T0.79x risk for psoriasisGood
- C;CNo summary available.Not rated
rs6887695Typical
- C;CnormalNot rated
- C;GNo summary available.Not rated
- G;G1.4x increased risk of psoriasis, psoriatic arthritisBad
rs11568506SLC22A4Typical
- G;Gcommon in complete genomicsGood
rs281875212CARD14Very important
- A;APsoriasis mutation (likely to be causative)Bad
- A;GPsoriasis mutation (likely to be causative)Bad
- G;Gcommon in clinvarGood
rs281875213CARD14Very important
- A;Acommon in clinvarGood
- A;GPsoriasis mutation (likely to be causative)Bad
- G;GPsoriasis mutation (likely to be causative)Bad
rs281875214CARD14Very important
- A;Acommon in clinvarGood
- A;CPsoriasis mutation (likely to be causative)Bad
- C;CPsoriasis mutation (likely to be causative)Bad
rs281875215CARD14Very important
- A;APsoriasis mutation (likely to be causative)Bad
- A;GPsoriasis mutation (likely to be causative)Bad
- G;Gcommon in clinvarGood
rs587777763CARD14Very important
- A;APsoriasis mutation (likely to be causative)Bad
- A;GPsoriasis mutation (likely to be causative)Bad
- G;Gcommon in clinvarGood
rs144475004CARD14Important
- C;CSignificant (6x) increase in risk for psoriasis, at least in AsiansBad
- C;GSignficant (6x) increase in risk for psoriasis, at least in AsiansBad
- G;Gcommon/normalGood

Other SNPs

No notable genotype or detailed notes

Show 18 SNPs

Source and license

Adapted from Psoriasis on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.

Linked SNPs

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Genes

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Other SNPs

Source and license