rs3213094

A SNP in the IL12B gene on chromosome 5. Its most notable genotype is T;T: 0.79x risk for psoriasis

Gene
IL12B
Location
Chr 5159,323,761 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA
Minor allele frequency
34%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. T;TMost notableGood0.79x risk for psoriasisTypical · 0.015% of people
  2. C;TGood0.79x risk for psoriasisTypical · 0.042% of people
  3. C;CNot ratedNo summary available.Typical · 0.043% of people

SNPedia records rs3213094 on the minus strand: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageT;T 15% C;T 42% C;C 43%
  • European ancestry (Utah)T;T <1% C;T 36% C;C 63%
  • Han Chinese (Beijing)T;T 15% C;T 54% C;C 31%
  • Japanese (Tokyo)T;T 32% C;T 44% C;C 24%
  • Yoruba (Nigeria)T;T 13% C;T 44% C;C 43%
  • African ancestry (Southwest US)T;T 12% C;T 35% C;C 53%
  • Chinese (Denver)T;T 23% C;T 46% C;C 31%
  • Gujarati IndianT;T 13% C;T 39% C;C 49%
  • Luhya (Kenya)T;T 17% C;T 49% C;C 34%
  • Mexican ancestry (Los Angeles)T;T 20% C;T 38% C;C 42%
  • Maasai (Kenya)T;T 6% C;T 42% C;C 51%
  • TuscanT;T 8% C;T 36% C;C 56%

Conditions, medicines and genes

Other IL12B SNPs

All IL12B SNPs

Notes

From SNPedia

Notes

23andMe blog psoriasis Chinese *rs3213094(C) 1.28x risk

Source and license

Adapted from rs3213094 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.