rs3212227

A SNP in the IL12B gene on chromosome 5. Its most notable genotype is G;T: Significantly increased risk of developing cervical cancer

Gene
IL12B
Location
Chr 5159,315,942 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
34%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. T;TBad1.43x increased risk of developing psoriasis and psoriatic arthritisMinor · 1.543% of people
  2. G;TMost notableBadSignificantly increased risk of developing cervical cancerWorth knowing · 2.043% of people
  3. G;GBadSignificantly increased risk of developing cervical cancerWorth knowing · 2.014% of people

SNPedia records rs3212227 on the minus strand: (A;A), (A;C), (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageT;T 43% G;T 43% G;G 14%
  • European ancestry (Utah)T;T 63% G;T 36% G;G <1%
  • Han Chinese (Beijing)T;T 31% G;T 55% G;G 15%
  • Japanese (Tokyo)T;T 24% G;T 45% G;G 31%
  • Yoruba (Nigeria)T;T 43% G;T 44% G;G 14%
  • African ancestry (Southwest US)T;T 51% G;T 37% G;G 12%
  • Chinese (Denver)T;T 32% G;T 46% G;G 21%
  • Gujarati IndianT;T 48% G;T 40% G;G 13%
  • Luhya (Kenya)T;T 34% G;T 48% G;G 18%
  • Mexican ancestry (Los Angeles)T;T 43% G;T 38% G;G 19%
  • Maasai (Kenya)T;T 47% G;T 46% G;G 6%
  • TuscanT;T 56% G;T 36% G;G 8%

Conditions, medicines and genes

Other IL12B SNPs

All IL12B SNPs

Notes

From SNPedia

Show notes, about 140 words

IL12B gene SNP, part of a haplotype with rs6887695 associated with psoriasis. A study of 500+ patients with psoriatic arthritis (PsA) concluded that the odds ratio for rs3212227(A;A) carriers was 1.43 (CI: 1.17-1.76). The effect sizes observed in patients with PsA appear to be smaller than those previously reported in patients with psoriasis, suggesting that both loci are primarily associated with psoriasis susceptibility rather than primarily with psoriatic arthritis. rs568408 GA/AA and rs3212227 AC/CC variant genotypes were associated with a significantly increased risk of cervical cancer [adjusted odds ratio, 1.43; 95% confidence interval (CI), 1.06-1.93; and adjusted odds ratio, 1.30; 95% CI, 0.97-1.75, respectively]. subjects carrying variant genotypes of both loci had a 1.82-fold (95% CI, 1.28-2.57) increased risk of cervical cancer

Source and license

Adapted from rs3212227 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.