rs144475004
A SNP in the CARD14 gene on chromosome 17. Its most notable genotype is C;C: Significant (6x) increase in risk for psoriasis, at least in Asians
- Gene
- CARD14
- Location
- Chr 1780,184,089 (GRCh38)
- Highest magnitude
- 3.5Important
- Tested on
- 23andMe
Genotypes
As shown in 23andMe and AncestryDNA files.
- C;CMost notableBadSignificant (6x) increase in risk for psoriasis, at least in Asians
- C;GBadSignficant (6x) increase in risk for psoriasis, at least in Asians
- G;GGoodcommon/normal
On SNPedia: (C;C), (C;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Conditions, medicines and genes
Other CARD14 SNPs
- rs281875212A;APsoriasis mutation (likely to be causative)Very important
- rs281875213A;GPsoriasis mutation (likely to be causative)Very important
- rs281875214A;CPsoriasis mutation (likely to be causative)Very important
- rs281875215A;APsoriasis mutation (likely to be causative)Very important
- rs387907240C;Cpityriasis rubra pilaris (PRP)Very important
- rs587777763A;APsoriasis mutation (likely to be causative)Very important
- rs11652075C;Ccommon in clinvarTypical
Notes
From SNPedia
Notes
rs144475004, also known as c.526G>C, p.Asp176His and D176H, represents a variant in the CARD14 gene on chromosome 17. In 416 psoriasis patients, the rs144475004(C) allele was associated in Asian individuals with generalized pustular psoriasis (odds ratio 6.4, p=8.4×10e-5), but no CARD14 mutations were found to be associated with other forms of psoriasis vulgaris (PV) or with pityriasis rubra pilaris (PRP).
C;C
see rs144475004
C;G
see rs144475004
Source and license
Adapted from rs144475004 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.