rs387907240
A SNP in the CARD14 gene on chromosome 17. Its most notable genotype is C;C: pityriasis rubra pilaris (PRP)
- Gene
- CARD14
- Location
- Chr 1780,184,030 (GRCh38)
- Highest magnitude
- 4.0Very important
- Tested on
- 23andMe, AncestryDNA
Genotypes
As shown in 23andMe and AncestryDNA files.
- C;CMost notableBadpityriasis rubra pilaris (PRP)
- C;TBadPityriasis rubra pilaris (PRP)
- T;TGoodcommon in clinvar
On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Conditions, medicines and genes
Other CARD14 SNPs
- rs281875212A;APsoriasis mutation (likely to be causative)Very important
- rs281875213A;GPsoriasis mutation (likely to be causative)Very important
- rs281875214A;CPsoriasis mutation (likely to be causative)Very important
- rs281875215A;APsoriasis mutation (likely to be causative)Very important
- rs587777763A;APsoriasis mutation (likely to be causative)Very important
- rs144475004C;CSignificant (6x) increase in risk for psoriasis, at least in AsiansImportant
- rs11652075C;Ccommon in clinvarTypical
Notes
From SNPedia
Notes
rs387907240, also known as c.467T>C, p.Leu156Pro and L156P, represents a very rare mutation in the CARD14 gene on chromosome 17. Found through sequencing of 2 unrelated 3-generation families with autosomal dominant pityriasis rubra pilaris, the rs387907240(C) mutation is considered causative for the condition.
C;C
see rs387907240
C;T
see rs387907240
Source and license
Adapted from rs387907240 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.