rs281875215
A SNP in the CARD14 gene on chromosome 17. Its most notable genotype is A;A: Psoriasis mutation (likely to be causative)
- Gene
- CARD14
- Location
- Chr 1780,182,790 (GRCh38)
- Highest magnitude
- 4.0Very important
- Tested on
- 23andMe, AncestryDNA
Genotypes
As shown in 23andMe and AncestryDNA files.
- A;AMost notableBadPsoriasis mutation (likely to be causative)
- A;GBadPsoriasis mutation (likely to be causative)
- G;GGoodcommon in clinvar
On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Conditions, medicines and genes
Other CARD14 SNPs
- rs281875212A;APsoriasis mutation (likely to be causative)Very important
- rs281875213A;GPsoriasis mutation (likely to be causative)Very important
- rs281875214A;CPsoriasis mutation (likely to be causative)Very important
- rs387907240C;Cpityriasis rubra pilaris (PRP)Very important
- rs587777763A;APsoriasis mutation (likely to be causative)Very important
- rs144475004C;CSignificant (6x) increase in risk for psoriasis, at least in AsiansImportant
- rs11652075C;Ccommon in clinvarTypical
Notes
From SNPedia
Notes
rs281875215, also known as c.349G>A, p.Gly117Ser and G117S, represents a rare mutation in the CARD14 gene on chromosome 17. This SNP is one of three CARD14 gain-of-function mutations found through sequencing families exhibiting autosomal dominantly inherited psoriasis.
A;A
see rs281875215
A;G
see rs281875215
Source and license
Adapted from rs281875215 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.