rs1265159

A SNP in the POU5F1 gene on chromosome 6. Its most notable genotype is A;A: 22.6x increased psoriasis risk for Chinese

Gene
POU5F1
Location
Chr 631,172,270 (GRCh38)
Highest magnitude
2.5Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
16%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. G;GNot ratednormalTypical · 0.069% of people
  2. A;GBad~5x increased risk of psoriasisTypical · 0.027% of people
  3. A;AMost notableNot rated22.6x increased psoriasis risk for ChineseWorth knowing · 2.54% of people

SNPedia records rs1265159 on the minus strand: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageG;G 69% A;G 27% A;A 4%
  • European ancestry (Utah)G;G 60% A;G 35% A;A 5%
  • Han Chinese (Beijing)G;G 85% A;G 15% A;A <1%
  • Japanese (Tokyo)G;G 97% A;G 3% A;A 0%
  • Yoruba (Nigeria)G;G 59% A;G 35% A;A 6%
  • African ancestry (Southwest US)G;G 49% A;G 39% A;A 12%
  • Chinese (Denver)G;G 86% A;G 13% A;A <1%
  • Gujarati IndianG;G 60% A;G 35% A;A 5%
  • Luhya (Kenya)G;G 54% A;G 39% A;A 7%
  • Mexican ancestry (Los Angeles)G;G 72% A;G 26% A;A 2%
  • Maasai (Kenya)G;G 67% A;G 31% A;A 3%
  • TuscanG;G 68% A;G 31% A;A 1%

Conditions, medicines and genes

Other POU5F1 SNPs

All POU5F1 SNPs

Notes

From SNPedia

Notes

23andMe blog psoriasis Chinese *rs1265159(A) 22.62x risk Proxy SNP for rs1265181 Note that in dbSNP orientation, the risk allele for this SNP is rs1265159(T); also, see rs1265181 for more information.

A;A

This has no known affect among Caucasian populations, but in a Chinese population this genotype indicates a 22x risk of psoriasis. Source Nature research paper

References

Source and license

Adapted from rs1265159 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.