rs1265159(A;A)

22.6x increased psoriasis risk for Chinese

Magnitude
2.5Worth knowing
Repute
Not rated
Frequency
4%Average of 11 populations
On SNPedia
rs1265159(T;T)Minus strand
Gene
POU5F1

Frequency

Share of people with A;A in each HapMap population.

  • African ancestry (Southwest US)12%
  • Luhya (Kenya)7%
  • Yoruba (Nigeria)6%
  • European ancestry (Utah)5%
  • Gujarati Indian5%
  • Maasai (Kenya)3%
  • Mexican ancestry (Los Angeles)2%
  • Tuscan1%
  • Chinese (Denver)<1%
  • Han Chinese (Beijing)<1%
  • Japanese (Tokyo)0%

Other genotypes of rs1265159

  1. G;GNot ratednormalTypical · 0.069% of people
  2. A;GBad~5x increased risk of psoriasisTypical · 0.027% of people

All about rs1265159

Notes

From SNPedia

This has no known affect among Caucasian populations, but in a Chinese population this genotype indicates a 22x risk of psoriasis. Source Nature research paper

References

Source and license

Adapted from rs1265159(T;T) on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.