rs1265181

A SNP on chromosome 6. Its most notable genotype is C;C: possibly increased risk of psoriasis

Gene
None listed
Location
Chr 631,188,008 (GRCh38)
Highest magnitude
2.5Worth knowing
Tested on
23andMe, AncestryDNA
Minor allele frequency
11%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. G;GGoodnormalTypical · 0.084% of people
  2. C;GBadincreased risk for psoriasisWorth knowing · 2.015% of people
  3. C;CMost notableBadpossibly increased risk of psoriasisWorth knowing · 2.52% of people

SNPedia records rs1265181 on the minus strand: (C;C), (C;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 4 HapMap populations.

  • AverageG;G 84% C;G 15% C;C 2%
  • European ancestry (Utah)G;G 55% C;G 39% C;C 6%
  • Han Chinese (Beijing)G;G 86% C;G 14% C;C 0%
  • Japanese (Tokyo)G;G 98% C;G 2% C;C 0%
  • Yoruba (Nigeria)G;G 95% C;G 5% C;C 0%

Conditions, medicines and genes

Notes

From SNPedia

Show notes, about 120 words

rs1265181 is a SNP in the HLA region of chromosome 6. A large study (>6,000 Chinese psoriasis patients and an equal number of controls) found a highly significant association between the minor rs1265181(G) allele and risk for psoriasis. A proxy for this allele is rs1265159(A). See also: 23andMe blog psoriasis

C;C

One paper claims a 22x risk of psoriasis among Asians, with no effect on non-asians. However it's an ambiguous flip on the minus strand, and occurs often among even the test genomes. Psoriasis doesn't seem to affect any of them so there is little reason to worry. But if you do have psoriasis and this genotype, please contact info@snpedia.com to discuss other neighboring snps on your platform. See the talk page for self reports.

Source and license

Adapted from rs1265181 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.