Alzheimer's disease

230 SNPs linked to Alzheimer's disease across 76 genes, 112 with a genotype of magnitude 2 or higher.

Type: Condition
SNPs: 230
Notable: 112Magnitude 2 or higher
Well documented: 109
Genes: 76

Linked SNPs

Every genotype, as shown in 23andMe and AncestryDNA files.

rs63749851PSEN2Very important
- A;Acommon in clinvarGood
- A;CEarly-onset Alzheimer's diseaseBad
rs63749891PSEN1Very important
- C;Gearly-onset Alzheimers diseaseBad
- G;Gcommon in clinvarGood
- G;TAlzheimer's disease, early-onset (reported)Bad
rs63749884PSEN2Very important
- A;Gearly-onset Alzheimer's disease; penetrance not 100%Bad
- G;Gcommon in clinvarGood
rs63750083PSEN1Very important
- A;CEarly-onset Alzheimer's; see discussionBad
- C;Ccommon in clinvarGood
rs63750231PSEN1Very important
- A;Acommon in clinvarGood
- A;CEarly-onset Alzheimer's disease (in some cases)Bad
- A;GEarly-onset Alzheimer's diseaseBad
rs281865161APPVery important
- GA;GAcommon in clinvarGood
- GA;TCAlzheimer's disease, familialBad
rs63749824PSEN1Very important
- C;Ccommon in clinvarGood
- C;Tassociated with Alzheimer's disease (either early- or late-onset)Bad
rs63749911PSEN1Very important
- C;TAlzheimer's diseaseBad
- T;Tcommon/normalGood
rs63750264APPVery important
- C;TAlzheimer's disease mutationBad
- C;GAlzheimer's disease mutationBad
- C;Ccommon in complete genomicsGood
- A;CAlzheimer's disease mutationBad
rs63750306PSEN1Very important
- A;Acommon in clinvarGood
- A;CAlzheimer's diseaseBad
- A;GAlzheimer's diseaseBad
- A;TAlzheimer's diseaseBad
rs63750391PSEN1Very important
- A;GAlzheimer's disease (reported; but see discussion)Bad
- C;GAlzheimer's disease (reported; but see discussion)Bad
- G;Gcommon in clinvarGood
- G;TAlzheimer's disease (reported; but see discussion)Bad
rs63750671APPVery important
- G;Gcommon in clinvarGood
- C;GSignificantly increased risk for early-onset Alzheimer's diseaseBad
rs193922916APPVery important
- G;Gcommon in clinvarGood
- A;GCarrier of an Alzheimer's disease mutationBad
- A;Asignificantly increased alzheimer's riskBad
rs367855127PSEN2Very important
- C;Ccommon/normalGood
- C;TPossible early-onset Alzheimer's disease mutation; see discussionBad
rs63750197PSEN2Very important
- C;Ccommon in clinvarGood
- C;Tlikely miscall for 23andMe and Ancestry users; otherwise, possible Alzheimer's disease association but causation unclear; dilated cardiomyopathyBad
rs104894002LOC105375056Very important
- G;Gcommon in clinvarGood
- A;GAlzheimer's, late-onset, possible/predictedBad
rs63750812PSEN2Very important
- A;GAlzheimer's disease association reported; see discussionBad
- G;Gcommon in clinvarGood
rs150400387PSEN2Very important
- C;Ccommon/normalGood
- C;TPossible Alzheimer's disease mutation - see discussionBad
rs61751103ADAM10Very important
- C;CcommonNot rated
- C;Grare mutation increasing risk for late-onset Alzheimer's diseaseBad
rs63750110PSEN2Very important
- A;Acommon in clinvarGood
- A;Cearly-onset Alzheimer's disease? or just a benign variant?Bad
rs63750847APPVery important
- T;Tresistance to Alzheimer's diseaseGood
- C;Tcarrier for reduced risk of Alzheimer's diseaseGood
- C;CnormalNot rated
rs142787485RAB10Very important
- A;Acommon/normalGood
- A;GPossibly lower odds (~0.65x) of developing Alzheimer's in individuals at higher risk for the disorderGood
- G;GPossibly lower odds (~0.65x) of developing Alzheimer's in individuals at higher risk for the disorderGood
rs75932628LOC105375056Important
- C;Ccommon in clinvarGood
- C;Trisk of Alzheimer's diseaseBad
- T;Trisk of Alzheimer's diseaseBad
rs5848GRNImportant
- T;TSomewhat increased (~2 - 3x) dementia riskBad
- C;TSomewhat increased (~2 - 3x) dementia riskBad
- C;Clower dementia riskGood
rs4420638APOC1Important
- A;ANormal/Average risk for Alzheimer'sGood
- A;G~3x increased Alzheimer's risk; 1.4x increased heart disease risk ; increased LDL cholesterolBad
- G;G2x+ increased Alzheimer's risk, further genotyping suggested ; increased LDL cholesterolBad
rs72824905PLCG2Important
- C;Ccommon/normalGood
- C;GModerate decrease (~0.6x) in risk for Alzheimer's disease as well as FTD and DLBGood
- G;GModerate decrease (~0.6x) in risk for Alzheimer's disease as well as FTD and DLBGood
rs6265BDNFWorth knowing
- T;Tintroversion; depression resistant; impaired motor skills learning; somewhat quicker mental decline in Alzheimer patientsBad
- C;TSlightly increased risk for ADHD or depression; somewhat quicker mental decline in Alzheimer patientsBad
- C;Ccommon/normalGood
rs1129844CCL11Worth knowing
- A;AUp to 10 year delay in onset of early-onset Alzheimer's (possibly)Good
- A;GSignificant delay in onset of early-onset Alzheimer's; possibly a 2.5 year delay in onset of late-onset Alzheimer'sGood
rs4986790TLR4Worth knowing
- A;AnormalGood
- A;GNo summary available.Not rated
- G;Gcomplex; numerous associations reportedBad
rs115550680ABCA7Worth knowing
- A;Acommon/normalGood
- A;GIncreased risk (~1.8x) of Alzheimer's, observed for African-AmericansBad
- G;GIncreased risk (~2.2x?) of Alzheimer's, observed for African-AmericansBad
rs5882CETPWorth knowing
- A;AFaster aging. Increased risk for Dementia. Less good cholesterol.Bad
- A;GLower risk of dementia and Alzheimer's disease. Higher good cholesterol.Good
- G;GLonger lifespan, 0.28x lower risk of dementia, 0.31x lower risk of Alzheimer's.Good
rs241448TAP2Worth knowing
- G;G2.14x increased risk for Alzheimer'sBad
- A;G1.51x increased risk for Alzheimer'sBad
- A;AcommonGood
rs2306402CTNNA3Worth knowing
- C;C1.18x increased risk for late-onset Alzheimer's diseaseBad
- C;T1.18x increased risk for late-onset Alzheimer's diseaseBad
- T;TnormalGood
rs669KLRG1Worth knowing
- T;TnormalGood
- C;Tpossibly increased risk for AlzheimersNot rated
- C;C3.8x or higher increased risk for AlzheimersBad
rs638405BACE1Worth knowing
- C;Cnormal riskNot rated
- C;Gnormal riskNot rated
- G;G2x increased ALZ risk in ApoE4 carriersBad
rs744373Worth knowing
- G;G1.28x risk of Alzheimer'sBad
- A;G1.13x risk of Alzheimer'sBad
- A;ANormalGood
rs1799724LOC100287329Worth knowing
- C;Cnormal riskGood
- C;Tif ApoE4(-), 1.6x risk of AD; if (+), 6.6x riskBad
- T;Tif ApoE4(-), 1.6x risk of AD; if (+), 6.6x riskBad
rs1800795IL6Worth knowing
- C;Cless IL6; certain risks, see detailsBad
- C;Gcomplex; see detailsNot rated
- G;Gmore IL6; certain risks, see detailsBad
rs2075650TOMM40Worth knowing
- A;Anormal; some association with greater longevityGood
- A;Gpossibly 2x higher Alzheimer's riskBad
- G;Gpossibly 4x higher Alzheimer's riskBad
rs2273647PPP4R3AWorth knowing
- C;CMost people have this genotype; but the rarer genotype may reduce Alzheimer's riskBad
- C;TSome protective effect against Alzheimer's by preventing brain glucose declineGood
rs3747742TREML2Worth knowing
- G;GNo summary available.Good
rs7101429GAB2Worth knowing
- A;Ahigher Alzheimer's risk if ApoE4 also presentBad
- A;G0.70x reduced risk for Alzheimer's riskGood
- G;G0.70x reduced risk for Alzheimer's riskGood
rs11190302Worth knowing
- C;CNo summary available.Good
- C;TNo summary available.Bad
- T;TNo summary available.Bad
rs12053868IL1RAPWorth knowing
- A;Acommon/normalGood
- A;Gpossibly faster amyloid accumulation in older (70+) adultsBad
- G;Gpossibly faster amyloid accumulation in older (70+) adultsBad
rs3865444CD33Minor
- C;Ccommon/normalNot rated
- A;Cslight reduction in risk for Alzheimer's diseaseGood
- A;Aslight reduction in risk for Alzheimer's diseaseGood
rs610932MS4A6AMinor
- T;TA allele associated with reduced risk of Alzheimer's in Chinese Han population.Good
- G;TNo summary available.Good
- G;GNo summary available.Bad
rs2177369CHATMinor
- G;G1.5x increased risk for Alzheimer's diseaseBad
- A;GnormalGood
- A;AnormalGood
rs2254958EIF2AK2Minor
- G;G1.61x reported increased risk for Alzheimer's; however, see comments on main rs-pageBad
- A;G1.24x reported increased risk for Alzheimer's; however, see comments on main rs-pageBad
- A;AcommonGood
rs3851179Minor
- T;T0.85x decreased risk for Alzheimer's diseaseGood
- C;T0.85x decreased risk for Alzheimer's diseaseGood
- C;CnormalBad
rs6656401CR1Minor
- A;A1.18x increased risk for late-onset Alzheimer’sBad
- A;G1.18x increased risk for late-onset Alzheimer’sBad
- G;Gcommon/normalGood
rs9886784Minor
- A;Amixed evidence of Alzheimer's disease riskBad
- A;CNo summary available.Not rated
- C;CaverageNot rated
rs11136000CLUMinor
- C;CnormalNot rated
- C;T0.84x decreased risk for Alzheimer's diseaseGood
- T;T0.84x decreased risk for Alzheimer's diseaseGood
rs429358APOEMinor
- C;Cone of 2 snps relevant to classifying APOE genotypeBad
- C;T>3x increased risk for Alzheimer's; 1.4x increased risk for heart diseaseBad
- T;TcommonGood
rs1049296TFMinor
- C;CC1 subtype of transferrin; common in clinvarGood
- C;THeterozygote carrying both C1 and C2 transferrin subtypes; very slightly higher risk for AlzheimersNot rated
- T;TC2 transferrin subtype; very slightly higher risk for AlzheimersNot rated
rs3818361CR1Minor
- G;GnormalNot rated
- A;G1.15x increased risk for late-onset Alzheimer'sBad
- A;A1.2x increased risk for late-onset Alzheimer'sBad
rs4880SOD2Minor
- G;Gcomplex! see rs4880Not rated
- A;Gcomplex! see rs4880Not rated
- A;Acomplex! see rs4880Not rated
rs1784931SORL1Minor
- A;AnormalNot rated
- A;CnormalNot rated
- C;Creduced risk for Alzheimers?Good
rs7412APOEMinor
- C;Cpart of APOE4 genoset evaluationNot rated
- C;Tpart of APOE4 genoset evaluationNot rated
- T;Tpart of APOE4 genoset evaluationNot rated
rs5030882TET1Minor
- C;CNo summary available.Not rated
- C;TNo summary available.Not rated
- T;TNo summary available.Not rated
rs6583817IDEMinor
- C;Ccommon in complete genomicsGood
- C;T~0.80x (lower) risk for late onset Alzheimer's diseaseGood
- T;T~0.80x (lower) risk for late onset Alzheimer's diseaseGood
rs7910977IDEMinor
- C;Ccommon in complete genomicsGood
- C;T~0.80x (lower) risk for late onset Alzheimer's diseaseNot rated
- T;T~0.80x (lower) risk for late onset Alzheimer's diseaseNot rated
rs2373115GAB2Typical
- C;CNo summary available.Not rated
- A;CnormalNot rated
- A;AnormalNot rated
rs688LDLRTypical
- C;Cnormal riskGood
- C;Tnormal risk for Alzheimer's; higher total and LDL cholesterol in femalesNot rated
- T;T1.5x higher risk for males of Alzheimer's; higher total and LDL cholesterol in femalesNot rated
rs1937TFAMTypical
- G;Gcommon on affy axiom dataGood
rs4934SERPINA3Typical
- A;A2.5x increased risk of Azheimer's and decreased age at onsetBad
- A;GNo summary available.Not rated
- G;GNo summary available.Good
rs7653SAR1ATypical
- A;Acommon/normalGood
rs8702KLC1Typical
- G;GaverageNot rated
- C;G?Not rated
- C;C0.2x risk for MSGood
rs242557MAPTTypical
- A;GnormalNot rated
- G;GNo summary available.Not rated
rs718265DHCR24Typical
- A;Acommon in clinvarGood
- G;GNo summary available.Not rated
rs726601SORL1Typical
- C;CnormalNot rated
- C;TnormalNot rated
- T;T0.86x risk for AlzheimersGood
rs733722CHATTypical
- C;Cno positive effect of AChE inhibitors for Alzheimer's patientsNot rated
- C;Tsome positive effect of AChE inhibitors for Alzheimer's patientsGood
- T;Tlargest positive effect of AChE inhibitors for Alzheimer's patientsNot rated
rs892086DNM2Typical
- C;TNo summary available.Not rated
- G;GnormalNot rated
- A;GnormalNot rated
- C;CNo summary available.Not rated
- A;A1.5x increased Alzheimer risk in non-ApoE4 carriersNot rated
rs908832ABCA2Typical
- A;A3.8x increased risk for early-onset AlzheimersNot rated
- A;GNo summary available.Not rated
- G;GnormalGood
rs911541ENTPD7Typical
- A;AnormalGood
- A;G1.58x increased risk of Alzheimer'sBad
- G;G1.48x increased risk of Alzheimer'sBad
rs1047552APH1BTypical
- G;G1.6x higher atherosclerosis risk only in malesNot rated
- G;T1.6x higher atherosclerosis risk only in malesNot rated
- T;TnormalGood
rs1050283OLR1Typical
- G;Gincreased risk for Alzheimer'sNot rated
- A;Gincreased risk for Alzheimer'sNot rated
- A;Anormal riskNot rated
rs1699103SORL1Typical
- T;TnormalNot rated
- C;TnormalNot rated
- G;GNo summary available.Not rated
- A;GNo summary available.Not rated
- C;C0.85x risk for AlzheimersNot rated
rs1792113SORL1Typical
- A;AnormalNot rated
- A;GnormalNot rated
- G;G0.90x risk for AlzheimersNot rated
rs1799752ACETypical
- -;-common in clinvarGood
- T;Tcommon in clinvarGood
rs1800871IL10Typical
- G;G0.5x decreased risk for endometriosisNot rated
- A;G0.5x decreased risk for endometriosisGood
- A;AnormalNot rated
rs1803274BCHETypical
- T;Tpossible increased Alzheimer's riskNot rated
- C;Tpossible increased Alzheimer's riskNot rated
- C;CnormalGood
rs1881747LOC105378305Typical
- C;C1.24x increased risk for LOADNot rated
- C;T1.24x increased risk for LOADNot rated
- T;TnormalNot rated
rs1982073TGFB1Typical
- G;Grisk genotype for several disordersNot rated
- A;Grisk genotype for several disordersNot rated
- A;Arisk genotype for several disordersNot rated
rs2071746HMOX1Typical
- A;AnormalNot rated
- A;TnormalNot rated
- T;Tmay be part of gs124Not rated
rs2160525LRP6Typical
- G;Gcommon in complete genomicsGood
rs2227564PLAUTypical
- T;Tcommon in clinvarGood
rs2229874LIMK2Typical
- G;Gcommon in complete genomicsGood
rs2230808ABCA1Typical
- T;Tcommon in clinvarGood
rs2279420Typical
- G;G0.79x decreased risk for LOADNot rated
- A;G0.79x decreased risk for LOADNot rated
- A;AnormalGood
rs2297404ABCA1Typical
- G;GNo summary available.Not rated
rs2333227MPOTypical
- C;CNo summary available.Not rated
- C;T0.8x decreased risk for lung cancer among smokers; increased gastric cancer riskNot rated
- T;T0.7x decreased risk for lung cancer among smokers; increased gastric cancer riskNot rated
rs3758505IDETypical
- A;Acommon in complete genomicsGood
rs3764650ABCA7Typical
- G;GLate onset?Not rated
- G;TLate onset?Not rated
- T;TnormalGood
rs3924999NRG1Typical
- C;TNo summary available.Not rated
rs4646954IDETypical
- G;Gcommon in complete genomicsGood
rs4878104DAPK1Typical
- C;TNo summary available.Not rated
rs5963409OTCTypical
- A;A1.19x increased risk for Alzheimer's diseaseBad
- A;G1.19x increased risk for Alzheimer's diseaseBad
- G;GnormalGood
rs5984894PCDH11XTypical
- G;GnormalNot rated
rs6494223CHRNA7Typical
- C;CnormalNot rated
- C;Tin ALZ patients, increased risk of delusionsNot rated
- T;Tin ALZ patients, increased risk of delusionsNot rated
rs6707013LINC01940Typical
- G;Gcommon in complete genomicsGood
rs7019241GOLM1Typical
- C;CaverageNot rated
- C;Treduced risk for AD?Not rated
- G;GNo summary available.Not rated
- T;Treduced risk for AD?Not rated
rs7561528LOC105373605Typical
- G;Gcommon/normalGood
rs10519262ATP8B4Typical
- A;A>1.9x risk for ADBad
- A;G1.9x risk for ADBad
- G;GaverageGood
rs10553596CASP7Typical
- TT;TTcommon/normalGood
rs10868366GOLM1Typical
- C;CNo summary available.Not rated
- G;GaverageNot rated
- G;Treduced risk for AD?Not rated
- T;Treduced risk for AD?Not rated
rs11030104BDNFTypical
- A;GNo summary available.Not rated
rs11218350SORL1Typical
- A;AnormalNot rated
- A;TnormalNot rated
- T;T0.83x risk for AlzheimersNot rated
rs11610206LOC105369746Typical
- T;Tcommon on affy axiom dataGood
rs11754661MTHFD1LTypical
- G;Gcommon on affy axiom dataGood
rs661PSEN1Very important
- A;Aearly onset Alzheimer's diseaseBad
- A;Gearly-onset Alzheimers diseaseBad
- G;GnormalGood
rs28936379PSEN2Very important
- A;Acommon in clinvarGood
- A;Gearly-onset Alzheimers diseaseBad
rs28936380PSEN2Very important
- C;Ccommon in clinvarGood
- C;Gearly-onset Alzheimer's diseaseBad
rs63749885PSEN1Very important
- C;Ccommon in clinvarGood
- C;Tearly-onset Alzheimers diseaseBad
rs63750577PSEN1Very important
- C;Ccommon in clinvarGood
- C;Tearly-onset Alzheimers diseaseBad
rs63750599PSEN1Very important
- C;Tearly-onset Alzheimers diseaseBad
- T;Tcommon in clinvarGood
rs63750815PSEN1Very important
- G;Gcommon in clinvarGood
- G;Tearly-onset Alzheimers diseaseBad
rs63750886PSEN1Very important
- C;Ccommon in clinvarGood
- C;Gearly-onset Alzheimers diseaseBad
rs63750900PSEN1Very important
- A;Gearly-onset Alzheimers diseaseBad
- G;Gcommon in clinvarGood
rs63751037PSEN1Very important
- A;Acommon in clinvarGood
- A;Gearly-onset Alzheimers diseaseBad
rs63751141PSEN1Very important
- C;Gearly-onset Alzheimers diseaseBad
- G;Gcommon in complete genomicsGood
rs63751144PSEN1Very important
- A;Cearly-onset Alzheimers diseaseBad
- C;Ccommon in clinvarGood
rs63751163PSEN1Very important
- C;Tearly-onset Alzheimers diseaseBad
- T;Tcommon in clinvarGood
rs63751223PSEN1Very important
- C;Gearly-onset Alzheimers diseaseBad
- G;Gcommon in clinvarGood
rs63751229PSEN1Very important
- C;Ccommon in clinvarGood
- C;Tearly-onset Alzheimers diseaseBad
rs63751320PSEN1Very important
- A;Acommon in clinvarGood
- A;Cearly-onset Alzheimers diseaseBad
rs61761208PSEN2Very important
- A;Acommon/normalGood
- A;TEarly-onset Alzheimer's mutation (reported)Bad
rs63750218PSEN1Very important
- C;TAlzheimers diseaseBad
- T;Tcommon in clinvarGood
rs63750307PSEN1Very important
- -;ATCATGEarly-onset Alzheimer's disease (predicted)Bad
- ATCATGDoes not lead to Early onset Alzheimer'sGood
- ATCATG;ATCATGcommon/normalGood
rs63750526PSEN1Very important
- A;Cearly-onset Alzheimers diseaseBad
- C;Ccommon in clinvarGood
rs63750590PSEN1Very important
- A;Acommon in clinvarGood
- A;Gearly onset Alzheimers diseaseBad
rs63750666PSEN2Very important
- C;Ccommon in clinvarGood
- C;Tearly-onset Alzheimer's disease; penetrance unclearBad
rs63750973APPVery important
- G;Gcommon in clinvarGood
- A;GConsidered pathogenic for an early-onset form of Alzheimer's diseaseBad
rs121917808PSEN1Very important
- A;CAlzheimer's disease, early-onset, as reportedBad
- C;Ccommon in clinvarGood
rs760892123Very important
- C;TEarly-onset Alzheimer's disease (predicted)Bad
- T;Tcommon/normalGood
i5047649Very important
- C;GAlzheimer's diseaseBad
- G;GAlzheimer's diseaseGood
rs63749805PSEN1Very important
- A;CAlzheimer's diseaseBad
- C;Ccommon/normalGood
- C;TAlzheimer's diseaseBad
rs63749810APPVery important
- C;TEarly-onset Alzheimer's diseaseBad
- C;Ccommon in clinvarGood
rs63749962PSEN1Very important
- C;TAlzheimer's disease (reported)Bad
- G;TAlzheimer's disease (reported)Bad
- T;Tcommon/normalGood
rs63749967PSEN1Very important
- C;GAlzheimer's disease (reported)Bad
- G;Gcommon/normalGood
rs63750004PSEN1Very important
- A;TAlzheimer's diseaseBad
- C;TAlzheimer's diseaseBad
- T;Tcommon/normalGood
rs63750066APPVery important
- C;TEarly-onset Alzheimer's diseaseBad
- C;Ccommon in clinvarGood
rs63750299PSEN1Very important
- G;TAlzheimer's diseaseBad
- T;Tcommon/normalGood
rs63750325PSEN1Very important
- A;TAlzheimer's diseaseBad
- T;Tcommon/normalGood
rs63750399APPVery important
- T;Tcommon in clinvarGood
- C;TMutation considered pathogenic for Alzheimer diseaseBad
- A;TMutation considered pathogenic for Alzheimer diseaseBad
rs63750450PSEN1Very important
- A;Acommon/normalGood
- A;GAlzheimer's disease (reported)Bad
rs63750550PSEN1Very important
- C;Ccommon/normalGood
- C;GAlzheimer's diseaseBad
- C;TAlzheimer's diseaseBad
rs63750730PSEN1Very important
- A;CAlzheimer's disease (reported)Bad
- C;Ccommon/normalGood
- C;TAlzheimer's disease (reported)Bad
rs63750734APPVery important
- C;TPathogenic mutation for Alzheimer diseaseBad
- C;Ccommon in clinvarGood
rs63750851APPVery important
- A;GEarly-onset Alzheimer's disease (possible)Bad
- A;Acommon/normalGood
rs63750868APPVery important
- A;GConsidered a pathogenic mutation for Alzheimer's diseaseBad
- A;Acommon/normalGood
rs63750907PSEN1Very important
- C;Ccommon/normalGood
- C;TAlzheimer's diseaseBad
rs63751039APPVery important
- T;Tcommon in clinvarGood
- C;TSignificantly increased risk for Alzheimer's diseaseBad
rs63751106PSEN1Very important
- A;TAlzheimer's diseaseBad
- C;TAlzheimer's diseaseBad
- T;Tcommon/normalGood
rs63751272PSEN1Very important
- A;Acommon in clinvarGood
- A;CAlzheimer's diseaseBad
- A;TAlzheimer's diseaseBad
rs63751441PSEN1Very important
- C;Ccommon/normalGood
- C;GAlzheimer's diseaseBad
rs63751484PSEN1Very important
- C;GAlzheimer's diseaseBad
- G;Gcommon/normalGood
rs533813519PSEN2Very important
- A;CEarly-onset Alzheimer's disease (predicted as possible)Bad
- C;Ccommon/normalGood
rs574125890PSEN2Very important
- G;Gcommon/normalGood
- G;TAlzheimer's disease (reported)Bad
rs755101354PSEN2Very important
- A;Acommon/normalGood
- A;GPossible (pathogenic) for early-onset Alzheimer'sBad
rs775145486PSEN2Very important
- C;Ccommon/normalGood
- C;GAlzheimer's disease (reported)Bad
rs777923890PSEN1Very important
- C;Ccommon/normalGood
- C;TEarly onset Alzheimer's association specifically in African-Americans?Bad
rs63750643APPVery important
- T;Tcommon in clinvarGood
- C;TSignificantly increased risk for Alzheimer's diseaseBad
rs145564988APPVery important
- C;GAlzheimer's disease (reported)Bad
- G;Gcommon/normalGood
rs149307620NOTCH3Very important
- C;Ccommon/normalGood
- C;TAlzheimer's disease, late-onset (possible/predicted)Bad
rs139709573TM2D3Very important
- A;GPossible link to late-onset Alzheimer's, at least in IcelandersBad
- G;Gcommon/normalGood
i6006817Very important
- C;Tsignificantly higher risk for Alzheimer's?Bad
i6006818Very important
- C;Gsignificantly higher risk for Alzheimer's?Bad
rs145518263ADAM10Very important
- C;Trare mutation increasing risk for late-onset Alzheimer's diseaseBad
- T;TcommonNot rated
rs10524523TOMM40Important
- -;-lower risk of late-onset Alzheimer's diseaseGood
- TTTTTTTTTTTTTTTTTTT;TTTTTTTTTTTTTTTTTTThigher risk for late-onset Alzheimer's diseaseBad
rs113809142ABCA7Important
- G;Gsomewhat higher risk for AlzheimersBad
- G;T~2x higher risk for Alzheimer's diseaseBad
- T;Tcommon/normalGood
rs200538373ABCA7Important
- C;Csomewhat higher risk for AlzheimersBad
- C;G~2x higher risk for Alzheimer's diseaseBad
- G;Gcommon/normalGood
rs72973581ABCA7Worth knowing
- A;ASomewhat (0.4x?) lower risk for Alzheimer's, according to one studyGood
- A;GSlightly lower risk (0.57x) for Alzheimer's, according to one studyGood
- G;Gcommon/normalGood
rs449647APOEWorth knowing
- T;Tlower levels of ApoEBad
- A;TPossibly lower levels of ApoEBad
- A;ANormal levels of ApoEGood
rs616338ABI3Worth knowing
- T;TModerate increase (1.43x) in risk for Alzheimer's diseaseBad
- C;TModerate increase (1.43x) in risk for Alzheimer's diseaseBad
- C;Ccommon/normalGood
rs78117248ABCA7Worth knowing
- A;Acommon/normalGood
- A;Grisk factor for Alzheimer disease (odds ratio ~2x)Bad
rs143332484LOC105375056Worth knowing
- C;Ccommon/normalGood
- C;TModerate increase (1.67x) in risk for Alzheimer's diseaseBad
- T;TModerate increase (1.67x) in risk for Alzheimer's diseaseBad
rs145999145PLD3Worth knowing
- A;A2x higher risk for Alzheimers diseaseBad
- A;G2x higher risk for Alzheimers diseaseBad
- G;GcommonGood

Genes

Genosets

Genosets combine several genotypes. Twofold checks them in your report.

Source and license

Adapted from Alzheimer's disease on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.