rs5882(G;G)

Longer lifespan, 0.28x lower risk of dementia, 0.31x lower risk of Alzheimer's.

Magnitude
2.1Worth knowing
Repute
Good
Frequency
26%Average of 11 populations
On SNPedia
rs5882(G;G)
Gene
CETP

Frequency

Share of people with G;G in each HapMap population.

  • Yoruba (Nigeria)45%
  • Luhya (Kenya)40%
  • Maasai (Kenya)38%
  • Japanese (Tokyo)29%
  • African ancestry (Southwest US)28%
  • Han Chinese (Beijing)23%
  • Chinese (Denver)22%
  • Mexican ancestry (Los Angeles)17%
  • European ancestry (Utah)16%
  • Gujarati Indian16%
  • Tuscan14%

Other genotypes of rs5882

  1. A;ABadFaster aging. Increased risk for Dementia. Less good cholesterol.Worth knowing · 2.027% of people
  2. A;GGoodLower risk of dementia and Alzheimer's disease. Higher good cholesterol.Worth knowing · 2.047% of people

All about rs5882

Notes

From SNPedia

This SNP has been related to exceptional long life. A study in Ashkenazi Jews showed that individuals with this genotype have significantly longer lifespans, and better cognitive function. ) Another study shows that this homozygote has an average 70% lower risk of dementia and Alzheimer's disease. This SNP might work by raising HDL ("good") cholesterol and lowering blood pressure.

References

Source and license

Adapted from rs5882(G;G) on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.