rs5882(A;A)

Faster aging. Increased risk for Dementia. Less good cholesterol.

Magnitude
2.0Worth knowing
Repute
Bad
Frequency
27%Average of 11 populations
On SNPedia
rs5882(A;A)
Gene
CETP

Frequency

Share of people with A;A in each HapMap population.

  • Tuscan45%
  • European ancestry (Utah)44%
  • Gujarati Indian34%
  • Mexican ancestry (Los Angeles)31%
  • Han Chinese (Beijing)29%
  • Chinese (Denver)27%
  • Japanese (Tokyo)24%
  • Maasai (Kenya)19%
  • African ancestry (Southwest US)18%
  • Luhya (Kenya)15%
  • Yoruba (Nigeria)12%

Other genotypes of rs5882

  1. A;GGoodLower risk of dementia and Alzheimer's disease. Higher good cholesterol.Worth knowing · 2.047% of people
  2. G;GMost notableGoodLonger lifespan, 0.28x lower risk of dementia, 0.31x lower risk of Alzheimer's.Worth knowing · 2.126% of people

All about rs5882

Notes

From SNPedia

This reduces HDL ("good") cholesterol. HDL cholesterol removes cholesterol from artery walls and improves health. This SNP seems to be associated with higher blood pressure, less longevity, and more diseases of aging, in particular memory decline and dementia, and lower odds of living to 100, especially in Ashkenazi Jews. Attempting to raise HDL cholesterol may (or may not) be useful to mitigate the effects of this SNP.

Source and license

Adapted from rs5882(A;A) on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.