rs5882

A SNP in the CETP gene on chromosome 16. Its most notable genotype is G;G: Longer lifespan, 0.28x lower risk of dementia, 0.31x lower risk of Alzheimer's.

Gene
CETP
Location
Chr 1656,982,180 (GRCh38)
Highest magnitude
2.1Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
45%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;ABadFaster aging. Increased risk for Dementia. Less good cholesterol.Worth knowing · 2.027% of people
  2. A;GGoodLower risk of dementia and Alzheimer's disease. Higher good cholesterol.Worth knowing · 2.047% of people
  3. G;GMost notableGoodLonger lifespan, 0.28x lower risk of dementia, 0.31x lower risk of Alzheimer's.Worth knowing · 2.126% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 27% A;G 47% G;G 26%
  • European ancestry (Utah)A;A 44% A;G 40% G;G 16%
  • Han Chinese (Beijing)A;A 29% A;G 47% G;G 23%
  • Japanese (Tokyo)A;A 24% A;G 47% G;G 29%
  • Yoruba (Nigeria)A;A 12% A;G 44% G;G 45%
  • African ancestry (Southwest US)A;A 18% A;G 54% G;G 28%
  • Chinese (Denver)A;A 27% A;G 51% G;G 22%
  • Gujarati IndianA;A 34% A;G 51% G;G 16%
  • Luhya (Kenya)A;A 15% A;G 46% G;G 40%
  • Mexican ancestry (Los Angeles)A;A 31% A;G 52% G;G 17%
  • Maasai (Kenya)A;A 19% A;G 44% G;G 38%
  • TuscanA;A 45% A;G 41% G;G 14%

Conditions, medicines and genes

Other CETP SNPs

All CETP SNPs

Notes

From SNPedia

Show notes, about 300 words

This SNP rs5882 in the CETP gene referred to as ILE405VAL and RSAI405V has been related to ageing and exceptional long life. A study in Ashkenazi Jews showed that individuals homozygotic for the G allele have significantly longer lifespans. New research also indicates that G homozygotes have an average of 70% less risk of dementia and Alzheimer's disease. The study also found that heterozygotes have a lower risk of dementia and Alzheimer's disease but more study is needed to determine the risk reduction for heterozygotes. See Association of a Functional Polymorphism in the Cholesteryl Ester Transfer Protein (CETP) Gene With Memory Decline and Incidence of Dementia and CETP Variant Linked to Slower Cognitive Decline and Reduced Dementia Risk .

A;A

This reduces HDL ("good") cholesterol. HDL cholesterol removes cholesterol from artery walls and improves health. This SNP seems to be associated with higher blood pressure, less longevity, and more diseases of aging, in particular memory decline and dementia, and lower odds of living to 100, especially in Ashkenazi Jews. Attempting to raise HDL cholesterol may (or may not) be useful to mitigate the effects of this SNP.

A;G

One copy of a longevity gene. This seems to raise HDL ("good") cholesterol, and reduce the risk of dementia and Alzheimer's disease. It may slightly increase longevity. It has been particularly studied in Ashkenazi Jews.

G;G

This SNP has been related to exceptional long life. A study in Ashkenazi Jews showed that individuals with this genotype have significantly longer lifespans, and better cognitive function. ) Another study shows that this homozygote has an average 70% lower risk of dementia and Alzheimer's disease. This SNP might work by raising HDL ("good") cholesterol and lowering blood pressure.

References

Source and license

Adapted from rs5882 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.