rs8702

A SNP in the KLC1 gene on chromosome 14. Its most notable genotype is G;G: average

Gene
KLC1
Location
Chr 14103,686,015 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe
Minor allele frequency
44%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. G;GMost notableNot ratedaverageTypical · 0.029% of people
  2. C;GNot rated?Typical · 0.049% of people
  3. C;CGood0.2x risk for MSTypical · 0.023% of people

SNPedia records rs8702 on the minus strand: (C;C), (C;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 4 HapMap populations.

  • AverageG;G 29% C;G 49% C;C 23%
  • European ancestry (Utah)G;G 52% C;G 38% C;C 10%
  • Han Chinese (Beijing)G;G 11% C;G 58% C;C 31%
  • Japanese (Tokyo)G;G 31% C;G 41% C;C 29%
  • Yoruba (Nigeria)G;G 21% C;G 58% C;C 21%

Conditions, medicines and genes

Notes

From SNPedia

Show notes, about 120 words

SNP rs8702, located in the KLC1 gene, has been reported to have a protective effect against the occurrence of multiple sclerosis. Specifically, the odds of a rs8702(G;G) individual - as oriented to the dbSNP entry, not as published - are reported to be 0.21 (CI: 0.018 - 0.88). A study of ~800 Swedish patients with Alzheimer's disease did not find an association to rs8702 independently, however, rs8702 interacted with ApoE4 carrier status in AD (p=0.006). Variability in the kinesin light chain 1 gene may influence risk of age-related cataract. Gene-environmental effects behind leukoaraiosis: a silent genetic variant of the kinesin protein can be activated in a subject with poorly controlled long-lasting hypertension.

Source and license

Adapted from rs8702 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.