rs744373

A SNP on chromosome 2. Its most notable genotype is G;G: 1.28x risk of Alzheimer's

Gene
None listed
Location
Chr 2127,137,039 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
37%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. G;GMost notableBad1.28x risk of Alzheimer'sWorth knowing · 2.015% of people
  2. A;GBad1.13x risk of Alzheimer'sWorth knowing · 2.047% of people
  3. A;AGoodNormalMinor · 1.038% of people

SNPedia records rs744373 on the minus strand: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageG;G 15% A;G 47% A;A 38%
  • European ancestry (Utah)G;G 12% A;G 40% A;A 49%
  • Han Chinese (Beijing)G;G 6% A;G 50% A;A 44%
  • Japanese (Tokyo)G;G 9% A;G 44% A;A 47%
  • Yoruba (Nigeria)G;G 27% A;G 52% A;A 21%
  • African ancestry (Southwest US)G;G 20% A;G 54% A;A 27%
  • Chinese (Denver)G;G 11% A;G 49% A;A 40%
  • Gujarati IndianG;G 5% A;G 34% A;A 61%
  • Luhya (Kenya)G;G 27% A;G 62% A;A 11%
  • Mexican ancestry (Los Angeles)G;G 14% A;G 47% A;A 40%
  • Maasai (Kenya)G;G 25% A;G 53% A;A 22%
  • TuscanG;G 9% A;G 38% A;A 54%

Conditions, medicines and genes

Notes

From SNPedia

Notes

rs6733839 and rs744373 are less than 2,000 base pairs apart,and they have similar ORs and MAFs. Therefore, it seems reasonable to suspect that these 2 SNPs are actually reporting the same signal.

Source and license

Adapted from rs744373 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.