rs78117248
A SNP in the ABCA7 gene on chromosome 19. Its most notable genotype is A;G: risk factor for Alzheimer disease (odds ratio ~2x)
- Gene
- ABCA7
- Location
- Chr 191,052,854 (GRCh38)
- Highest magnitude
- 2.0Worth knowing
- Tested on
- Not on consumer chips
Genotypes
As shown in 23andMe and AncestryDNA files.
- A;AGoodcommon/normal
- A;GMost notableBadrisk factor for Alzheimer disease (odds ratio ~2x)
On SNPedia: (A;A), (A;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Conditions, medicines and genes
Other ABCA7 SNPs
- rs113809142G;Gsomewhat higher risk for AlzheimersImportant
- rs200538373C;Csomewhat higher risk for AlzheimersImportant
- rs72973581A;ASomewhat (0.4x?) lower risk for Alzheimer's, according to one studyWorth knowing
- rs115550680G;GIncreased risk (~2.2x?) of Alzheimer's, observed for African-AmericansWorth knowing
- rs3752246C;Ccommon on affy axiom dataTypical
- rs3764650G;GLate onset?Typical
- rs4147918A;Acommon genotypeTypical
Notes
From SNPedia
Notes
Sequencing of the ABCA7 gene in a Belgian cohort of 700+ patients with Alzheimer's disease led to the association of the rare rs78117248(G) allele with increased risk (odds ratio 2.07, CI: 1.31-3.27, p=0.0016).
A;G
see discussion at rs78117248
Source and license
Adapted from rs78117248 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.