rs113809142
A SNP in the ABCA7 gene on chromosome 19. Its most notable genotype is G;G: somewhat higher risk for Alzheimers
- Gene
- ABCA7
- Location
- Chr 191,056,245 (GRCh38)
- Highest magnitude
- 3.0Important
- Tested on
- Not on consumer chips
Genotypes
As shown in 23andMe and AncestryDNA files.
- G;GMost notableBadsomewhat higher risk for Alzheimers
- G;TBad~2x higher risk for Alzheimer's disease
- T;TGoodcommon/normal
On SNPedia: (G;G), (G;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Conditions, medicines and genes
Other ABCA7 SNPs
- rs200538373C;Csomewhat higher risk for AlzheimersImportant
- rs72973581A;ASomewhat (0.4x?) lower risk for Alzheimer's, according to one studyWorth knowing
- rs115550680G;GIncreased risk (~2.2x?) of Alzheimer's, observed for African-AmericansWorth knowing
- rs78117248A;Grisk factor for Alzheimer disease (odds ratio ~2x)Worth knowing
- rs3752246C;Ccommon on affy axiom dataTypical
- rs3764650G;GLate onset?Typical
- rs4147918A;Acommon genotypeTypical
Notes
From SNPedia
Notes
rs113809142, also known as c.4416+2T>G, is one of several loss-of-function ABCA7 mutations associated with Alzheimer's disease initially in Icelanders, and then replicated in other populations. Carriers of one rare rs113809142(G) allele are at roughly more than twice the risk for developing late-onset Alzheimer's disease compared to people having the most common genotype (T;T); the odds ratio is 4.47, p=3.4 × 10e−7.
G;G
see discussion at rs113809142
G;T
see discussion at rs113809142
Source and license
Adapted from rs113809142 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.