rs3764650

A SNP in the ABCA7 gene on chromosome 19. Its most notable genotype is G;G: Late onset?

Gene
ABCA7
Location
Chr 191,046,521 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
20%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. G;GMost notableNot ratedLate onset?Typical · 0.07% of people
  2. G;TNot ratedLate onset?Typical · 0.032% of people
  3. T;TGoodnormalTypical · 0.061% of people

On SNPedia: (G;G), (G;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageG;G 7% G;T 32% T;T 61%
  • European ancestry (Utah)G;G 3% G;T 16% T;T 81%
  • Han Chinese (Beijing)G;G 4% G;T 45% T;T 51%
  • Japanese (Tokyo)G;G 18% G;T 45% T;T 37%
  • Yoruba (Nigeria)G;G 9% G;T 42% T;T 50%
  • African ancestry (Southwest US)G;G 7% G;T 32% T;T 61%
  • Chinese (Denver)G;G 11% G;T 47% T;T 42%
  • Gujarati IndianG;G 4% G;T 20% T;T 76%
  • Luhya (Kenya)G;G 12% G;T 41% T;T 47%
  • Mexican ancestry (Los Angeles)G;G 0% G;T 7% T;T 93%
  • Maasai (Kenya)G;G 6% G;T 39% T;T 55%
  • TuscanG;G 3% G;T 22% T;T 76%

Conditions, medicines and genes

Other ABCA7 SNPs

All ABCA7 SNPs

Notes

From SNPedia

Notes

Alzheimer's disease associated, based on large 2011 study "The minor allele of Rs3764650 in ABCA7 was associated with a later age at onset and shorter disease course" according to http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3511432/

Source and license

Adapted from rs3764650 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.