rs115550680
A SNP in the ABCA7 gene on chromosome 19. Its most notable genotype is G;G: Increased risk (~2.2x?) of Alzheimer's, observed for African-Americans
- Gene
- ABCA7
- Location
- Chr 191,050,421 (GRCh38)
- Highest magnitude
- 2.5Worth knowing
- Tested on
- 23andMe, AncestryDNA
- Minor allele frequency
- 2%
Genotypes
As shown in 23andMe and AncestryDNA files.
- A;AGoodcommon/normal
- A;GBadIncreased risk (~1.8x) of Alzheimer's, observed for African-Americans
- G;GMost notableBadIncreased risk (~2.2x?) of Alzheimer's, observed for African-Americans
On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Conditions, medicines and genes
Other ABCA7 SNPs
- rs113809142G;Gsomewhat higher risk for AlzheimersImportant
- rs200538373C;Csomewhat higher risk for AlzheimersImportant
- rs72973581A;ASomewhat (0.4x?) lower risk for Alzheimer's, according to one studyWorth knowing
- rs78117248A;Grisk factor for Alzheimer disease (odds ratio ~2x)Worth knowing
- rs3752246C;Ccommon on affy axiom dataTypical
- rs3764650G;GLate onset?Typical
- rs4147918A;Acommon genotypeTypical
Notes
From SNPedia
Show notes, about 130 words
A 2013 meta-analysis comprising a total of ~2,000 African-Americans with late-onset Alzheimer's disease found that rs115550680(G) was associated with higher risk for the disorder in this population (OR 1.79, CI: 1.47-2.12, p = 2.2 × 10e-9). This SNP was is in (80-90%) linkage disequilibrium with SNPs previously associated with Alzheimer disease in Europeans. In 2016, a publication reported that a 44-base pair deletion (rs142076058) co-segregated with both Alzheimer's and rs115550680(G).This deletion is common in African-American Alzheimer cases (15.2%) and controls (9.74%), but is rare (0.12%) in a non-Hispanic white cohort. The deleted allele could result in defective protein function and be an ethnic-specific pathogenic alteration.
A;G
see rs115550680
G;G
see rs115550680
Source and license
Adapted from rs115550680 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.