rs72973581
A SNP in the ABCA7 gene on chromosome 19. Its most notable genotype is A;A: Somewhat (0.4x?) lower risk for Alzheimer's, according to one study
- Gene
- ABCA7
- Location
- Chr 191,043,104 (GRCh38)
- Highest magnitude
- 2.5Worth knowing
- Tested on
- Not on consumer chips
Genotypes
As shown in 23andMe and AncestryDNA files.
- A;AMost notableGoodSomewhat (0.4x?) lower risk for Alzheimer's, according to one study
- A;GGoodSlightly lower risk (0.57x) for Alzheimer's, according to one study
- G;GGoodcommon/normal
On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Conditions, medicines and genes
Other ABCA7 SNPs
- rs113809142G;Gsomewhat higher risk for AlzheimersImportant
- rs200538373C;Csomewhat higher risk for AlzheimersImportant
- rs115550680G;GIncreased risk (~2.2x?) of Alzheimer's, observed for African-AmericansWorth knowing
- rs78117248A;Grisk factor for Alzheimer disease (odds ratio ~2x)Worth knowing
- rs3752246C;Ccommon on affy axiom dataTypical
- rs3764650G;GLate onset?Typical
- rs4147918A;Acommon genotypeTypical
Notes
From SNPedia
Notes
A sequencing study of 332 sporadic Alzheimer's disease cases identified this ABCA7 coding variant, rs72973581(A), also known as p.G215S, as conferring a modest but statistically significant protection against the disorder (OR 0.57, CI: 0.41-0.8, p = 0.024).
A;A
see rs72973581
A;G
see rs72973581
Source and license
Adapted from rs72973581 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.