rs6494223

A SNP in the CHRNA7 gene on chromosome 15. Its most notable genotype is C;C: normal

Gene
CHRNA7
Location
Chr 1532,104,256 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
46%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableNot ratednormalTypical · 0.028% of people
  2. C;TNot ratedin ALZ patients, increased risk of delusionsTypical · 0.048% of people
  3. T;TNot ratedin ALZ patients, increased risk of delusionsTypical · 0.024% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 28% C;T 48% T;T 24%
  • European ancestry (Utah)C;C 34% C;T 50% T;T 16%
  • Han Chinese (Beijing)C;C 13% C;T 54% T;T 33%
  • Japanese (Tokyo)C;C 16% C;T 46% T;T 38%
  • Yoruba (Nigeria)C;C 25% C;T 50% T;T 25%
  • African ancestry (Southwest US)C;C 33% C;T 46% T;T 21%
  • Chinese (Denver)C;C 11% C;T 47% T;T 42%
  • Gujarati IndianC;C 27% C;T 55% T;T 18%
  • Luhya (Kenya)C;C 40% C;T 41% T;T 19%
  • Mexican ancestry (Los Angeles)C;C 29% C;T 52% T;T 19%
  • Maasai (Kenya)C;C 42% C;T 40% T;T 18%
  • TuscanC;C 36% C;T 47% T;T 17%

Conditions, medicines and genes

Notes

From SNPedia

Notes

A significant association between delusions and the rs6494223(T) allele (odds ratio 1.63, CI: 1.22-2.17, p = 0.014, ) was found in a cohort of Alzheimer's disease patients in Northern Ireland.

Source and license

Adapted from rs6494223 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.