rs1050283

A SNP in the OLR1 gene on chromosome 12. Its most notable genotype is G;G: increased risk for Alzheimer's

Gene
OLR1
Location
Chr 1210,159,690 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
35%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. G;GMost notableNot ratedincreased risk for Alzheimer'sTypical · 0.055% of people
  2. A;GNot ratedincreased risk for Alzheimer'sTypical · 0.034% of people
  3. A;ANot ratednormal riskTypical · 0.012% of people

SNPedia records rs1050283 on the minus strand: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 10 HapMap populations.

  • AverageG;G 55% A;G 34% A;A 12%
  • European ancestry (Utah)G;G 23% A;G 52% A;A 25%
  • Han Chinese (Beijing)G;G 60% A;G 33% A;A 7%
  • Japanese (Tokyo)G;G 68% A;G 27% A;A 5%
  • Yoruba (Nigeria)G;G 76% A;G 22% A;A 2%
  • African ancestry (Southwest US)G;G 60% A;G 33% A;A 7%
  • Chinese (Denver)G;G 54% A;G 35% A;A 11%
  • Gujarati IndianG;G 57% A;G 37% A;A 6%
  • Luhya (Kenya)G;G 74% A;G 24% A;A 2%
  • Maasai (Kenya)G;G 56% A;G 37% A;A 8%
  • TuscanG;G 18% A;G 38% A;A 44%

Conditions, medicines and genes

Other OLR1 SNPs

All OLR1 SNPs

Notes

From SNPedia

Notes

rs1050283, a SNP also known as +1073, is located in the 3' untranslated region of the oxidized low density lipoprotein (lectin-like) receptor 1 OLR1 gene, which is also known as the LOX-1 gene. The rs1050283(C) allele has been associated with increased risk for Alzheimer's disease in several studies of ~200 Southern Italian Alzheimer patients. The risk is independent of ApoE status, and may also be defined by haplotypes including one or both of neighboring SNPs rs12316150 and rs669.PMID 15860461, PMID 18191876

Source and license

Adapted from rs1050283 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.