rs61751103

A SNP in the ADAM10 gene on chromosome 15. Its most notable genotype is C;G: rare mutation increasing risk for late-onset Alzheimer's disease

Gene
ADAM10
Location
Chr 1558,665,172 (GRCh38)
Highest magnitude
4.0Very important
Tested on
Not on consumer chips

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CNot ratedcommonTypical · 0.0
  2. C;GMost notableBadrare mutation increasing risk for late-onset Alzheimer's diseaseVery important · 4.0

On SNPedia: (C;C), (C;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Conditions, medicines and genes

Other ADAM10 SNPs

All ADAM10 SNPs

Notes

From SNPedia

Notes

rs61751103, also known as Q170H or Gln170His, is a SNP in the ADAM metallopeptidase domain 10 ADAM10 gene. The common allele is rs61751103(C) (in the FWD direction, not in the mRNA), encoding the Gln. The rs61751103(G) allele was found in 11 of 16 individuals affected by Alzheimer's disease (average onset age 69.5 years) from seven late-onset AD families. This mutation was also found in at least one unaffected subject, implying incomplete penetrance. This SNP is referred to as i6006818 by 23andMe.

Source and license

Adapted from rs61751103 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.