rs145518263

A SNP in the ADAM10 gene on chromosome 15. Its most notable genotype is C;T: rare mutation increasing risk for late-onset Alzheimer's disease

Gene
ADAM10
Location
Chr 1558,665,141 (GRCh38)
Highest magnitude
4.0Very important
Tested on
AncestryDNA

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;TMost notableBadrare mutation increasing risk for late-onset Alzheimer's diseaseVery important · 4.0
  2. T;TNot ratedcommonTypical · 0.0

On SNPedia: (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Conditions, medicines and genes

Other ADAM10 SNPs

All ADAM10 SNPs

Notes

From SNPedia

Notes

rs145518263, also known as R181G or Arg181Gly, is a SNP in the ADAM metallopeptidase domain 10 ADAM10 gene. The common allele is rs145518263(T), encoding the Arg. The rs145518263(C) allele was found in 11 of 16 individuals affected by Alzheimer's disease (average onset age 69.5 years) from seven late-onset AD families. This mutation was also found in at least one unaffected subject, implying incomplete penetrance. This SNP is referred to as i6006817 by 23andMe.

Source and license

Adapted from rs145518263 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.