rs1799724
A SNP in the LOC100287329 gene on chromosome 6. Its most notable genotype is C;T: if ApoE4(-), 1.6x risk of AD; if (+), 6.6x risk
- Gene
- LOC100287329
- Location
- Chr 631,574,705 (GRCh38)
- Highest magnitude
- 2.0Worth knowing
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
- Minor allele frequency
- 10%
Genotypes
As shown in 23andMe and AncestryDNA files.
- C;CGoodnormal risk
- C;TMost notableBadif ApoE4(-), 1.6x risk of AD; if (+), 6.6x risk
- T;TBadif ApoE4(-), 1.6x risk of AD; if (+), 6.6x risk
On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 4 HapMap populations.
- AverageC;C 82% C;T 13% T;T 5%
- European ancestry (Utah)C;C 90% C;T 7% T;T 3%
- Han Chinese (Beijing)C;C 69% C;T 24% T;T 7%
- Japanese (Tokyo)C;C 76% C;T 13% T;T 11%
- Yoruba (Nigeria)C;C 93% C;T 7% T;T 0%
Related
Conditions, medicines and genes
Other LOC100287329 SNPs
Notes
From SNPedia
Show notes, about 180 words
rs1799724, a SNP near the tumor necrosis factor TNF gene, was found in a study of ~500 Caucasians to be both an independent risk factor for the development of Alzheimer's disease and also a modifier of the risk for individuals carrying ApoE4 alleles. On its own, the rs1799724(T) allele led to an odds ratio of 1.63 (CI: 1.13-2.34, p=0.009). In carriers of ApoE4 alleles, the odds ratio changed from 2.92 (CI: 2.00-4.27) in the absence of rs1799724(T) to an OR of 6.65 (CI: 3.26-13.55, p=0.03) in its presence. Note, however, that this study is from 2005 and it does not appear to have been independently replicated since then (which is why the magnitude is 2, i.e. pretty low on the 0-10 magnitude scale). In a Chinese study , post-menopausal women were significantly more likely to have low bone mineral density if they had *CC-AA genotypes in rs1799724-rs1800629 * a haplotype of rs1799724-rs1800629-rs6254-rs6256-IL-1ra-rs2227956-rs1801197 news cigarette smoking and gastric cancer risk
C;T
Note summary is based on a single report from 2005.
T;T
Note summary is based on a single report from 2005.
Source and license
Adapted from rs1799724 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.