rs2071746

A SNP in the HMOX1 gene on chromosome 22. Its most notable genotype is A;A: normal

Gene
HMOX1
Location
Chr 2235,380,679 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe
Minor allele frequency
50%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableNot ratednormalTypical · 0.027% of people
  2. A;TNot ratednormalTypical · 0.041% of people
  3. T;TNot ratedmay be part of gs124Typical · 0.033% of people

On SNPedia: (A;A), (A;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 4 HapMap populations.

  • AverageA;A 27% A;T 41% T;T 33%
  • European ancestry (Utah)A;A 35% A;T 39% T;T 26%
  • Han Chinese (Beijing)A;A 33% A;T 36% T;T 31%
  • Japanese (Tokyo)A;A 27% A;T 50% T;T 23%
  • Yoruba (Nigeria)A;A 11% A;T 38% T;T 51%

Conditions, medicines and genes

Other HMOX1 SNPs

All HMOX1 SNPs

Notes

From SNPedia

Notes

A case-control study of 300 patients with Alzheimer's disease found that subjects carrying both the rs2071746(T;T) and rs242557(A;A) genotypes had a 6.65x increased risk (CI: 1.12-39.29; p = 0.037) compared to subjects without these risk genotypes. This combination of SNPs is encapsulated in the gs124 genoset.

Source and license

Adapted from rs2071746 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.