rs7910977

A SNP in the IDE gene on chromosome 10. Its most notable genotype is C;T: ~0.80x (lower) risk for late onset Alzheimer's disease

Gene
IDE
Location
Chr 1092,450,119 (GRCh38)
Highest magnitude
1.0Minor
Tested on
23andMe
Minor allele frequency
18%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CGoodcommon in complete genomicsTypical · 0.065% of people
  2. C;TMost notableNot rated~0.80x (lower) risk for late onset Alzheimer's diseaseMinor · 1.031% of people
  3. T;TNot rated~0.80x (lower) risk for late onset Alzheimer's diseaseMinor · 1.05% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 65% C;T 31% T;T 5%
  • European ancestry (Utah)C;C 75% C;T 22% T;T 3%
  • Han Chinese (Beijing)C;C 67% C;T 30% T;T 3%
  • Japanese (Tokyo)C;C 56% C;T 34% T;T 11%
  • Yoruba (Nigeria)C;C 51% C;T 41% T;T 8%
  • African ancestry (Southwest US)C;C 40% C;T 53% T;T 7%
  • Chinese (Denver)C;C 69% C;T 30% T;T <1%
  • Gujarati IndianC;C 66% C;T 31% T;T 3%
  • Luhya (Kenya)C;C 73% C;T 24% T;T 4%
  • Mexican ancestry (Los Angeles)C;C 59% C;T 33% T;T 9%
  • Maasai (Kenya)C;C 76% C;T 22% T;T 3%
  • TuscanC;C 81% C;T 18% T;T 1%

Conditions, medicines and genes

Other IDE SNPs

All IDE SNPs

Notes

From SNPedia

Show notes, about 150 words

rs7910977 is a SNP of the IDE gene, which encodes the insulin-degrading enzyme. Late onset Alzheimer's disease is a neurodegenerative condition in which the brain develops large numbers of extracellular senile plaques composed primarily of aggregated amyloid-B proteins as well as intraneuronal neurofibrillary tangles composed mainly of aggregated tau protein. One notable function of insulin-degrading enzyme is its ability to degrade amyloid-B and therefore to influence the amount of amyloid-B found in the brain. The rs7910977(T) allele is associated with reduced risk of Alzheimer's disease in one study of ~3,000 patients, and in this study, the conclusion was that it was most likely due to near perfect linkage with rs6583817, a nearby functional variant. rs6583817(T) allele carriers had an odds ratio for late onset Alzheimer's disease of around 0.80 (p<0.03).

Source and license

Adapted from rs7910977 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.