rs4646954
A SNP in the IDE gene on chromosome 10. Its most notable genotype is G;G: common in complete genomics
- Gene
- IDE
- Location
- Chr 1092,574,070 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, FamilyTreeDNA
- Minor allele frequency
- 18%
Genotypes
As shown in 23andMe and AncestryDNA files.
On SNPedia: (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 10 HapMap populations.
- AverageG;G 59%
- Han Chinese (Beijing)G;G 74%
- Japanese (Tokyo)G;G 55%
- Yoruba (Nigeria)G;G 34%
- African ancestry (Southwest US)G;G 33%
- Chinese (Denver)G;G 77%
- Gujarati IndianG;G 70%
- Luhya (Kenya)G;G 37%
- Mexican ancestry (Los Angeles)G;G 69%
- Maasai (Kenya)G;G 59%
- TuscanG;G 86%
Related
Conditions, medicines and genes
Other IDE SNPs
- rs6583817C;T~0.80x (lower) risk for late onset Alzheimer's diseaseMinor
- rs7910977C;T~0.80x (lower) risk for late onset Alzheimer's diseaseMinor
- rs3758505A;Acommon in complete genomicsTypical
- rs3781239C;Ccommon in complete genomicsTypical
- rs4646958T;Tcommon in complete genomicsTypical
- rs7895832A;Acommon in complete genomicsTypical
- rs17107734C;Ccommon in complete genomicsTypical
Notes
From SNPedia
Notes
rs3758505, rs4646953 and rs4646954 influence Alzheimer's disease
Source and license
Adapted from rs4646954 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.