rs72824905

A SNP in the PLCG2 gene on chromosome 16. Its most notable genotype is C;G: Moderate decrease (~0.6x) in risk for Alzheimer's disease as well as FTD and DLB

Gene
PLCG2
Location
Chr 1681,908,423 (GRCh38)
Highest magnitude
3.0Important
Tested on
Not on consumer chips

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CGoodcommon/normalTypical · 0.0
  2. C;GMost notableGoodModerate decrease (~0.6x) in risk for Alzheimer's disease as well as FTD and DLBImportant · 3.0
  3. G;GGoodModerate decrease (~0.6x) in risk for Alzheimer's disease as well as FTD and DLBImportant · 3.0

On SNPedia: (C;C), (C;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Conditions, medicines and genes

Notes

From SNPedia

Show notes, about 130 words

The minor allele of this variant, rs72824905 (p.Pro522Arg), found in the PLCG2 gene, is reported to somewhat reduce risk for Alzheimer's disease (OR 0.68, p = 5.38 × 10e-10). This protein is highly expressed in microglia and demonstrates immune interactions associated with AD. In a 2019 study including 4,985 patients with Alzheimer's (AD), 2,437 with frontotemporal demential (FTD), and 1,446 with dementia with Lewy bodies (DLB), the rs72824905-G allele was also found to reduce risk (by about half) not only for AD but also for FTD and DLB. Perhaps for this reason (or some related reason?) rs72824905-G carriers were also more likely to live to age 90, and there was even greater prevalence of the allele among centenarians. An AlzForum post about this finding is here.

C;G

see rs72824905

G;G

see rs72824905

Source and license

Adapted from rs72824905 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.