rs760892123

A SNP. Its most notable genotype is C;T: Early-onset Alzheimer's disease (predicted)

Gene
None listed
Highest magnitude
8.0Very important
Tested on
Not on consumer chips

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;TMost notableBadEarly-onset Alzheimer's disease (predicted)Very important · 8.0
  2. T;TGoodcommon/normalTypical · 0.0

On SNPedia: (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Conditions, medicines and genes

Notes

From SNPedia

Notes

aka c.1247T>C (p.Ile416Thr or I416T) A clinical and genetic evaluation of 93 related individuals from a Colombian admixed population concluded that Ile416Thr, a mutation in the PSEN1 gene, is a dominantly inherited pathogenic variant causing early-onset Alzheimer's disease.

C;T

see text on main rs-page for details

Source and license

Adapted from rs760892123 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.