rs2177369

A SNP in the CHAT gene on chromosome 10. Its most notable genotype is G;G: 1.5x increased risk for Alzheimer's disease

Gene
CHAT
Location
Chr 1049,635,683 (GRCh38)
Highest magnitude
1.5Minor
Tested on
23andMe
Minor allele frequency
28%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. G;GMost notableBad1.5x increased risk for Alzheimer's diseaseMinor · 1.5
  2. A;GGoodnormalTypical · 0.0
  3. A;AGoodnormalTypical · 0.0

SNPedia records rs2177369 on the minus strand: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Conditions, medicines and genes

Other CHAT SNPs

All CHAT SNPs

Notes

From SNPedia

Notes

A case-control study of 471 Italian late-onset Alzheimer's disease patients aged 60 years or older, and 254 subjects with no neurodegenerative disorders serving as the control group, found that the rs2177369(G;G) genotype (in dbSNP orientation) a risk factor with an odds ratio of 1.56 (CI: 1.10-2.22, p = 0.01). Refreshingly, the authors call their results "far from definitive". A meta-analysis of 16,000 Alzheimer's cases finds that rs2177369 is associated (albeit not with a high odds ratio) with the disease in Caucasians.

Source and license

Adapted from rs2177369 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.