rs4838544

A SNP in the CHAT gene on chromosome 10. Its most notable genotype is A;A: common in complete genomics

Gene
CHAT
Location
Chr 1049,648,606 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, FamilyTreeDNA
Minor allele frequency
3%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableGoodcommon in complete genomicsTypical · 0.091% of people
  2. G;GGoodcommon in clinvarTypical · 0.0<1% of people

On SNPedia: (A;A), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 10 HapMap populations.

  • AverageA;A 91% G;G <1%
  • European ancestry (Utah)A;A 100% G;G 0%
  • Han Chinese (Beijing)A;A 100% G;G 0%
  • Japanese (Tokyo)A;A 100% G;G 0%
  • Yoruba (Nigeria)A;A 66% G;G 4%
  • African ancestry (Southwest US)A;A 90% G;G 2%
  • Chinese (Denver)A;A 99% G;G 0%
  • Luhya (Kenya)A;A 78% G;G <1%
  • Mexican ancestry (Los Angeles)A;A 98% G;G 0%
  • Maasai (Kenya)A;A 77% G;G 1%
  • TuscanA;A 99% G;G 0%

Other CHAT SNPs

All CHAT SNPs

Notes

From SNPedia

Notes

Replication and extension of association of choline acetyltransferase with nicotine dependence in European and African American smokers.

Source and license

Adapted from rs4838544 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.