rs733722

A SNP in the CHAT gene on chromosome 10. Its most notable genotype is C;C: no positive effect of AChE inhibitors for Alzheimer's patients

Gene
CHAT
Location
Chr 1049,608,897 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
27%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableNot ratedno positive effect of AChE inhibitors for Alzheimer's patientsTypical · 0.053% of people
  2. C;TGoodsome positive effect of AChE inhibitors for Alzheimer's patientsTypical · 0.037% of people
  3. T;TNot ratedlargest positive effect of AChE inhibitors for Alzheimer's patientsTypical · 0.010% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 53% C;T 37% T;T 10%
  • European ancestry (Utah)C;C 58% C;T 37% T;T 4%
  • Han Chinese (Beijing)C;C 34% C;T 45% T;T 22%
  • Japanese (Tokyo)C;C 39% C;T 46% T;T 15%
  • Yoruba (Nigeria)C;C 74% C;T 23% T;T 3%
  • African ancestry (Southwest US)C;C 68% C;T 28% T;T 4%
  • Chinese (Denver)C;C 25% C;T 57% T;T 18%
  • Gujarati IndianC;C 53% C;T 41% T;T 7%
  • Luhya (Kenya)C;C 67% C;T 29% T;T 4%
  • Mexican ancestry (Los Angeles)C;C 31% C;T 47% T;T 22%
  • Maasai (Kenya)C;C 67% C;T 31% T;T 3%
  • TuscanC;C 64% C;T 29% T;T 7%

Conditions, medicines and genes

Other CHAT SNPs

All CHAT SNPs

Notes

From SNPedia

Notes

rs733722, also known as -5293C>T, is a SNP near the choline acetyltransferase CHAT gene. A study of 121 Alzheimer's disease patients treated primarily with the acetylcholinesterase (AChE) inhibitors donepezil or galantamine found different rates of mental decline depending on rs733722 genotypes. Individuals of rs733722(C;C) genotype effectively showed declines in cognition over time equivalent to untreated patients, whereas rs733722(C;T) individuals showed less decline, and rs733722(T;T) patients had a negligible decline over the course of the study (~15 months). An earlier study by these authors found no association between SNPs in this gene and actual risk for Alzheimer's.

Source and license

Adapted from rs733722 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.