rs11136000
A SNP in the CLU gene on chromosome 8. Its most notable genotype is C;T: 0.84x decreased risk for Alzheimer's disease
- Gene
- CLU
- Location
- Chr 827,607,002 (GRCh38)
- Highest magnitude
- 1.5Minor
- Tested on
- 23andMe, AncestryDNA
- Minor allele frequency
- 38%
Genotypes
As shown in 23andMe and AncestryDNA files.
- C;CNot ratednormal
- C;TMost notableGood0.84x decreased risk for Alzheimer's disease
- T;TGood0.84x decreased risk for Alzheimer's disease
On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageC;C 39% C;T 44% T;T 18%
- European ancestry (Utah)C;C 41% C;T 49% T;T 11%
- Han Chinese (Beijing)C;C 63% C;T 34% T;T 4%
- Japanese (Tokyo)C;C 60% C;T 35% T;T 5%
- Yoruba (Nigeria)C;C 14% C;T 55% T;T 31%
- African ancestry (Southwest US)C;C 16% C;T 51% T;T 33%
- Chinese (Denver)C;C 55% C;T 39% T;T 6%
- Gujarati IndianC;C 52% C;T 39% T;T 10%
- Luhya (Kenya)C;C 17% C;T 45% T;T 38%
- Mexican ancestry (Los Angeles)C;C 48% C;T 33% T;T 19%
- Maasai (Kenya)C;C 25% C;T 53% T;T 22%
- TuscanC;C 35% C;T 49% T;T 16%
Related
Conditions, medicines and genes
Genosets
Genosets combine several genotypes. Twofold checks them in your report.
Notes
From SNPedia
Show notes, about 190 words
rs11136000 is a SNP associated with the clusterin CLU gene, which has also been known as the APOJ gene. A study of over 5,000 Alzheimer's disease patients (and over 10,000 controls) found a slight protective effect of the (T) allele of this SNP. rs11136000(T) carriers had a slightly decreased risk for Alzheimer's disease, with an odds ratio of 0.84 (CI: 0.8-0.9, p=1.4x10e-9). The association of this SNP and late-onset Alzheimer's disease was replicated over a total of another 1829 cases (and 2576 controls). A MRI study of ~400 young (average age: 23) healthy carriers of rs11136000(C) alleles found a distinct profile of lower white matter integrity in these individuals that may increase their vulnerability to developing Alzheimer's later in life. To put it another way, 50 years before the actual development of Alzheimer's, most of us - after all, the (C) allele is the common one - apparently show some evidence of weakness in myelin, the protective covering around the neuron’s axons in the brain, (slightly) predisposing us to late-onset Alzheimer’s, at least compared to carriers of one or two (T) alleles.
Source and license
Adapted from rs11136000 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.