rs142787485

A SNP in the RAB10 gene on chromosome 2. Its most notable genotype is A;G: Possibly lower odds (~0.65x) of developing Alzheimer's in individuals at higher risk for the disorder

Gene
RAB10
Location
Chr 226,135,287 (GRCh38)
Highest magnitude
4.0Very important
Tested on
Not on consumer chips

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AGoodcommon/normalTypical · 0.0
  2. A;GMost notableGoodPossibly lower odds (~0.65x) of developing Alzheimer's in individuals at higher risk for the disorderVery important · 4.0
  3. G;GGoodPossibly lower odds (~0.65x) of developing Alzheimer's in individuals at higher risk for the disorderVery important · 4.0

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Conditions, medicines and genes

Other RAB10 SNPs

All RAB10 SNPs

Notes

From SNPedia

Show notes, about 140 words

rs142787485 represents a rare variant in the RAB10 gene on chromosome 2. A 2017 publication reports that the rs142787485(G) allele may be associated with a lower odds of developing Alzheimer's disease in individuals otherwise at higher risk for the disorder. In ~400 individuals from the ADNI cohort tested, the rs142787485(G) allele carriers had an odds ratio of 0.58 (p value = 0.018) compared to non-carriers; in ~500 individuals from the CCS cohort tested, rs142787485(G) carriers had an odds ratio of 0.69 (CI:0.47–0.99; p value 0.028). Another SNP, rs7653, showed a similar protective effect but did not replicate in a second population tested. The 2017 publication describes the same research cited in a report from ICAD 2016 (page 4 and page 9 of this pdf.

A;G

see discussion at rs142787485

G;G

see discussion at rs142787485

Source and license

Adapted from rs142787485 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.