rs2373115

A SNP in the GAB2 gene on chromosome 11. Its most notable genotype is C;C.

Gene
GAB2
Location
Chr 1178,380,104 (GRCh38)
Highest magnitude
0.1Typical
Tested on
23andMe, AncestryDNA
Minor allele frequency
29%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. C;CMost notableNot ratedNo summary available.Typical · 0.143% of people
  2. A;CNot ratednormalTypical · 0.046% of people
  3. A;ANot ratednormalTypical · 0.011% of people

SNPedia records rs2373115 on the minus strand: (G;G), (G;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 43% A;C 46% A;A 11%
  • European ancestry (Utah)C;C 77% A;C 20% A;A 3%
  • Han Chinese (Beijing)C;C 41% A;C 43% A;A 16%
  • Japanese (Tokyo)C;C 27% A;C 50% A;A 23%
  • Yoruba (Nigeria)C;C 43% A;C 47% A;A 10%
  • African ancestry (Southwest US)C;C 33% A;C 53% A;A 14%
  • Chinese (Denver)C;C 35% A;C 54% A;A 11%
  • Gujarati IndianC;C 44% A;C 49% A;A 8%
  • Luhya (Kenya)C;C 42% A;C 53% A;A 6%
  • Mexican ancestry (Los Angeles)C;C 47% A;C 43% A;A 10%
  • Maasai (Kenya)C;C 32% A;C 52% A;A 16%
  • TuscanC;C 57% A;C 39% A;A 4%

Conditions, medicines and genes

Other GAB2 SNPs

All GAB2 SNPs

Notes

From SNPedia

Show notes, about 250 words

Conflicting reports of possible small increase in Alzheimer's risk. Currently dubious at best. rs2373115 is one of several SNPs in the GAB2 gene indicating an increased risk (OR 4.1) of late-onset Alzheimer's disease, but apparently only in individuals also carrying ApoE4 alleles, i.e. rs429358(C) alleles rs2373115 marker does not modify the risk of Alzheimer's disease in Spanish APOE e4 carriers. rs2373115(G) is the risk allele. (p = 9 x 10(-11)) was associated with an odds ratio of 4.06 (confidence interval 2.81-14.69) However, a separate study of 1,749 Alzheimer patients concluded that this GAB2 SNP is "at best a minor genetic determinant" since the authors of this study observed only a slight tendency for an increase of the (G;G) genotype (odds ratio of 1.3 vs (G;T) and (T;T), CI:1.0-1.6, p=0.09) and for an increase in the G allele frequency (odds ratio 1.3, CI:1.0-1.6, p=0.05) in ApoE4-carriers. A new (Dec 2008) meta-analysis concludes that, yes, indeed, rs2373115 is associated with increased risk for Alzheimer's disease among ApoE4 carriers, with an odds ratio of 1.58 (CI: 1.17 - 2.14, p = 3 x 10e-3), but only among carriers. This meta-analysis pooled published studies with a new study of 443 AD cases. A study of 579 Italian Alzheimer's patients saw this association, but only in ApoE4 non-carriers, suggesting it might be an independent risk factor for the disease.

C;C

Conflicting reports of possible small increase in Alzheimer's risk. Currently dubious at best.

Source and license

Adapted from rs2373115 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.