rs7101429

A SNP in the GAB2 gene on chromosome 11. Its most notable genotype is G;G: 0.70x reduced risk for Alzheimer's risk

Gene
GAB2
Location
Chr 1178,281,921 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
23%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;ABadhigher Alzheimer's risk if ApoE4 also presentTypical · 0.061% of people
  2. A;GGood0.70x reduced risk for Alzheimer's riskMinor · 1.833% of people
  3. G;GMost notableGood0.70x reduced risk for Alzheimer's riskWorth knowing · 2.07% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 61% A;G 33% G;G 7%
  • European ancestry (Utah)A;A 75% A;G 23% G;G 2%
  • Han Chinese (Beijing)A;A 42% A;G 42% G;G 17%
  • Japanese (Tokyo)A;A 26% A;G 51% G;G 23%
  • Yoruba (Nigeria)A;A 95% A;G 5% G;G <1%
  • African ancestry (Southwest US)A;A 91% A;G 9% G;G 0%
  • Chinese (Denver)A;A 34% A;G 55% G;G 11%
  • Gujarati IndianA;A 42% A;G 50% G;G 9%
  • Luhya (Kenya)A;A 89% A;G 11% G;G 0%
  • Mexican ancestry (Los Angeles)A;A 47% A;G 47% G;G 7%
  • Maasai (Kenya)A;A 70% A;G 28% G;G 3%
  • TuscanA;A 57% A;G 39% G;G 4%

Conditions, medicines and genes

Other GAB2 SNPs

All GAB2 SNPs

Notes

From SNPedia

Notes

rs7101429 is a SNP in the GRB2-associated binding protein 2 GAB2 gene. In a study of 4000 DNA samples from ~1300 families affected by Alzheimer's disease, there was a reduced risk (0.70x; p = .002) among carriers of the rs7101429(G) minor allele.

Source and license

Adapted from rs7101429 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.