rs1129844(A;A)

Up to 10 year delay in onset of early-onset Alzheimer's (possibly)

Magnitude
2.5Worth knowing
Repute
Good
On SNPedia
rs1129844(A;A)
Gene
CCL11

Other genotypes of rs1129844

  1. A;GGoodSignificant delay in onset of early-onset Alzheimer's; possibly a 2.5 year delay in onset of late-onset Alzheimer'sWorth knowing · 2.0

All about rs1129844

Notes

From SNPedia

One publication reports that the (A;G) genotype of rs1129844 might delay by up to 10 years early-onset Alzheimer's disease caused by a mutation in the PSEN1 gene. It is not clear whether an Alzheimer's risk benefit might result from the (A;A) genotype. See additional discussion at rs1129844, and the citation to the study in which Supplementary Figure 5 shows a statistically nonsignificant, although positive, trend towards delayed onset of dementia in a UCSF patient cohort of late-onset Alzheimer's patients carrying the (A;A) rs1129844 genotype. This should be viewed cautiously until confirmed in larger Alzheimer's populations.

Source and license

Adapted from rs1129844(A;A) on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.