rs1049296
A SNP in the TF gene on chromosome 3. Its most notable genotype is T;T: C2 transferrin subtype; very slightly higher risk for Alzheimers
- Gene
- TF
- Location
- Chr 3133,775,510 (GRCh38)
- Highest magnitude
- 1.2Minor
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
- Minor allele frequency
- 15%
Genotypes
As shown in 23andMe and AncestryDNA files.
- C;CGoodC1 subtype of transferrin; common in clinvar
- C;TNot ratedHeterozygote carrying both C1 and C2 transferrin subtypes; very slightly higher risk for Alzheimers
- T;TMost notableNot ratedC2 transferrin subtype; very slightly higher risk for Alzheimers
On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageC;C 70% C;T 27% T;T 3%
- European ancestry (Utah)C;C 74% C;T 24% T;T 2%
- Han Chinese (Beijing)C;C 57% C;T 34% T;T 9%
- Japanese (Tokyo)C;C 59% C;T 34% T;T 7%
- Yoruba (Nigeria)C;C 90% C;T 10% T;T 0%
- African ancestry (Southwest US)C;C 83% C;T 16% T;T 2%
- Chinese (Denver)C;C 57% C;T 38% T;T 6%
- Gujarati IndianC;C 63% C;T 34% T;T 3%
- Luhya (Kenya)C;C 85% C;T 16% T;T 0%
- Mexican ancestry (Los Angeles)C;C 74% C;T 26% T;T 0%
- Maasai (Kenya)C;C 60% C;T 38% T;T 2%
- TuscanC;C 71% C;T 28% T;T 2%
Related
Conditions, medicines and genes
Other TF SNPs
Genosets
- Gs293Increased risk of Alzheimer's disease, consider reducing iron levelsVery important
- Gs292possible 2x increased risk of Alzheimer's disease for some people but maybe not others; see discussionWorth knowing
- Gs315Reduced risk of PD in a haplotype with the C2 variant in the TF geneWorth knowing
- Gs317Parkinson's risk might be decreased depending upon determination of haplotype phaseWorth knowing
Genosets combine several genotypes. Twofold checks them in your report.
Notes
From SNPedia
Show notes, about 160 words
rs1049296, also known as Pro570Ser, is best known as the basis for the C1/C2 subtypes of the transferrin TF gene. The rs1049296(C) allele encodes the C1 subtype, and the rarer rs1049296(T) allele encodes the C2 subtype. Involved in the transport of iron, transferrin and its subtypes have been linked at times to various conditions, perhaps most notably Alzheimer's disease. One meta-analyis of 19 studies with 6310 cases and 13661 controls concluded that the C2 allele, rs1049296(T), was associated with slightly increased risk for Alzheimer's, with odds ratios around 1.1-1.2. Pathogens may scavenge iron, and the body's attempts to sequester it from such pathogens are a form of defense termed nutritional immunity. One explanation for the presence of the C2 TF subtype in humans is that it may reduce the effectiveness of some bacterial transferrin binding proteins.arstechnica.com
Source and license
Adapted from rs1049296 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.