rs6265(C;T)

Slightly increased risk for ADHD or depression; somewhat quicker mental decline in Alzheimer patients

Magnitude
2.6Worth knowing
Repute
Bad
Frequency
27%Average of 10 populations
On SNPedia
rs6265(A;G)Minus strand
Gene
BDNF

Frequency

Share of people with C;T in each HapMap population.

  • Chinese (Denver)49%
  • Han Chinese (Beijing)47%
  • Japanese (Tokyo)43%
  • Tuscan36%
  • European ancestry (Utah)34%
  • Gujarati Indian28%
  • Mexican ancestry (Los Angeles)26%
  • African ancestry (Southwest US)9%
  • Maasai (Kenya)2%
  • Yoruba (Nigeria)<1%

Other genotypes of rs6265

  1. T;TMost notableBadintroversion; depression resistant; impaired motor skills learning; somewhat quicker mental decline in Alzheimer patientsWorth knowing · 2.68% of people
  2. C;CGoodcommon/normalTypical · 0.064% of people

All about rs6265

Notes

From SNPedia

Some studies indicate that this genotype is associated with slightly increased risk for certain mental health disorders; other studies have found no association. PMID 20682308 PMID 20087404 ]PMID 20033742 PMID 19699537 PMID 18286632 PMID 15940292 PMID 20943059 PMID 19603419 PMID 18600033 Also, On a driving-based motor learning task subjects with this genotype showed greater error during short-term learning and poorer retention over 4 days, relative to subjects without the polymorphism. The presence of this BDNF polymorphism is associated with differences in brain motor system function, altered short-term plasticity, and greater error in short-term motor learning. wiredscience/2009/10/ genetically-bad-driving/ Wired discusses the research as does 10/30/snpwatch-the-bad- driving-gene/ 23andMe blog. PMID 17293537 Alzheimer's disease risk for non ApoE4 carriers is affected by the heterozygous form of rs6265

References

Source and license

Adapted from rs6265(A;G) on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.