rs6265(T;T)
Introversion; depression resistant; impaired motor skills learning; somewhat quicker mental decline in Alzheimer patients
- Magnitude
- 2.6Worth knowing
- Repute
- Bad
- Frequency
- 8%Average of 10 populations
- On SNPedia
- rs6265(A;A)Minus strand
- Gene
- BDNF
Frequency
Share of people with T;T in each HapMap population.
- Han Chinese (Beijing)26%
- Chinese (Denver)24%
- Japanese (Tokyo)17%
- Mexican ancestry (Los Angeles)7%
- Tuscan6%
- European ancestry (Utah)3%
- Gujarati Indian2%
- Yoruba (Nigeria)0%
- African ancestry (Southwest US)0%
- Maasai (Kenya)0%
Other genotypes of rs6265
Notes
From SNPedia
Met/Met (higher risk) variant of the Val66Met SNP in the BDNF gene that codes for brain-derived neurotrophic factor. Met/Met is associated in some (but not all) studies with slightly increased susceptibility to certain mental health disorders such as ADHD and depression. PMID 20042999 associated with introversion This genotype may provide resistance to depression when subjected to repeated defeat blog summary On a driving-based motor learning task subjects with this genotype showed greater error during short-term learning and poorer retention over 4 days, relative to subjects without the polymorphism. The presence of this BDNF polymorphism is associated with differences in brain motor system function, altered short-term plasticity, and greater error in short-term motor learning. Wired discusses the research as does 23andMe blog.
References
Related
Source and license
Adapted from rs6265(A;A) on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.