rs892086

A SNP in the DNM2 gene on chromosome 19. Its most notable genotype is C;T.

Gene
DNM2
Location
Chr 1910,727,001 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
47%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. C;TMost notableNot ratedNo summary available.Typical · 0.00% of people
  2. G;GNot ratednormalTypical · 0.021% of people
  3. A;GNot ratednormalTypical · 0.051% of people
  4. C;CNot ratedNo summary available.Typical · 0.00% of people
  5. A;ANot rated1.5x increased Alzheimer risk in non-ApoE4 carriersTypical · 0.028% of people

SNPedia records rs892086 on the minus strand: (A;G), (C;C), (C;T), (G;G), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;T 0% G;G 21% A;G 51% C;C 0% A;A 28%
  • European ancestry (Utah)C;T 0% G;G 21% A;G 45% C;C 0% A;A 34%
  • Han Chinese (Beijing)C;T 0% G;G 35% A;G 51% C;C 0% A;A 14%
  • Japanese (Tokyo)C;T 0% G;G 31% A;G 58% C;C 0% A;A 11%
  • Yoruba (Nigeria)C;T 0% G;G 11% A;G 49% C;C 0% A;A 40%
  • African ancestry (Southwest US)C;T 0% G;G 12% A;G 46% C;C 0% A;A 42%
  • Chinese (Denver)C;T 0% G;G 28% A;G 50% C;C 0% A;A 22%
  • Gujarati IndianC;T 0% G;G 17% A;G 51% C;C 0% A;A 33%
  • Luhya (Kenya)C;T 0% G;G 13% A;G 59% C;C 0% A;A 28%
  • Mexican ancestry (Los Angeles)C;T 0% G;G 12% A;G 48% C;C 0% A;A 40%
  • Maasai (Kenya)C;T 0% G;G 21% A;G 53% C;C 0% A;A 26%
  • TuscanC;T 0% G;G 30% A;G 54% C;C 0% A;A 16%

Conditions, medicines and genes

Other DNM2 SNPs

All DNM2 SNPs

Notes

From SNPedia

Notes

Carriers with late-onset Alzheimer's disease who have rs892086(T;T) genotypes appear to have less DNM2 mRNA in their brains, according to a study of 429 Japanese patients, and among non-ApoE4 carriers, appear to be at increased risk for developing Alzheimer's disease. The odds ratio reported is 1.53 (CI: 1.08-2.17, p=0.015).

Source and license

Adapted from rs892086 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.