rs2279420

A SNP on chromosome 10. Its most notable genotype is G;G: 0.79x decreased risk for LOAD

Gene
None listed
Location
Chr 1060,022,189 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
8%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. G;GMost notableNot rated0.79x decreased risk for LOADTypical · 0.0<1% of people
  2. A;GNot rated0.79x decreased risk for LOADTypical · 0.012% of people
  3. A;AGoodnormalTypical · 0.088% of people

SNPedia records rs2279420 on the minus strand: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageG;G <1% A;G 12% A;A 88%
  • European ancestry (Utah)G;G 2% A;G 14% A;A 84%
  • Han Chinese (Beijing)G;G 0% A;G 12% A;A 88%
  • Japanese (Tokyo)G;G 2% A;G 13% A;A 85%
  • Yoruba (Nigeria)G;G 0% A;G 4% A;A 96%
  • African ancestry (Southwest US)G;G 0% A;G 11% A;A 90%
  • Chinese (Denver)G;G <1% A;G 15% A;A 84%
  • Gujarati IndianG;G 0% A;G 10% A;A 90%
  • Luhya (Kenya)G;G <1% A;G 11% A;A 88%
  • Mexican ancestry (Los Angeles)G;G 0% A;G 14% A;A 86%
  • Maasai (Kenya)G;G 0% A;G 11% A;A 89%
  • TuscanG;G 1% A;G 16% A;A 83%

Conditions, medicines and genes

Notes

From SNPedia

Notes

Nominally significant association found for this SNP with late-onset Alzheimer's disease (odds ratio 0.79, p=0.022) in a study of ~1000 Caucasian patients, but it would not have withstood statistical correction for multiple testing.

Source and license

Adapted from rs2279420 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.