rs11218350

A SNP in the SORL1 gene on chromosome 11. Its most notable genotype is A;A: normal

Gene
SORL1
Location
Chr 11121,581,942 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, FamilyTreeDNA
Minor allele frequency
32%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableNot ratednormalTypical · 0.013% of people
  2. A;TNot ratednormalTypical · 0.036% of people
  3. T;TNot rated0.83x risk for AlzheimersTypical · 0.051% of people

On SNPedia: (A;A), (A;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 13% A;T 36% T;T 51%
  • European ancestry (Utah)A;A 5% A;T 40% T;T 55%
  • Han Chinese (Beijing)A;A 34% A;T 43% T;T 23%
  • Japanese (Tokyo)A;A 20% A;T 51% T;T 28%
  • Yoruba (Nigeria)A;A <1% A;T 10% T;T 89%
  • African ancestry (Southwest US)A;A 0% A;T 19% T;T 81%
  • Chinese (Denver)A;A 31% A;T 51% T;T 18%
  • Gujarati IndianA;A 24% A;T 53% T;T 24%
  • Luhya (Kenya)A;A 3% A;T 25% T;T 73%
  • Mexican ancestry (Los Angeles)A;A 24% A;T 38% T;T 38%
  • Maasai (Kenya)A;A 2% A;T 35% T;T 63%
  • TuscanA;A 4% A;T 28% T;T 68%

Conditions, medicines and genes

Other SORL1 SNPs

All SORL1 SNPs

Notes

From SNPedia

Notes

rs11218350 is among several SNPs in the SORL1 gene that show some association with increased (or decreased) risk for Alzheimer's disease in a study of 1,400 Caucasians.

Source and license

Adapted from rs11218350 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.