rs3851179

A SNP on chromosome 11. Its most notable genotype is T;T: 0.85x decreased risk for Alzheimer's disease

Gene
None listed
Location
Chr 1186,157,598 (GRCh38)
Highest magnitude
1.5Minor
Tested on
23andMe, AncestryDNA
Minor allele frequency
33%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. T;TMost notableGood0.85x decreased risk for Alzheimer's diseaseMinor · 1.512% of people
  2. C;TGood0.85x decreased risk for Alzheimer's diseaseMinor · 1.537% of people
  3. C;CBadnormalTypical · 0.052% of people

SNPedia records rs3851179 on the minus strand: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageT;T 12% C;T 37% C;C 52%
  • European ancestry (Utah)T;T 18% C;T 47% C;C 35%
  • Han Chinese (Beijing)T;T 19% C;T 52% C;C 29%
  • Japanese (Tokyo)T;T 17% C;T 46% C;C 37%
  • Yoruba (Nigeria)T;T 0% C;T 14% C;C 86%
  • African ancestry (Southwest US)T;T 0% C;T 25% C;C 75%
  • Chinese (Denver)T;T 14% C;T 53% C;C 33%
  • Gujarati IndianT;T 16% C;T 45% C;C 39%
  • Luhya (Kenya)T;T 3% C;T 22% C;C 76%
  • Mexican ancestry (Los Angeles)T;T 26% C;T 36% C;C 38%
  • Maasai (Kenya)T;T 1% C;T 22% C;C 76%
  • TuscanT;T 17% C;T 41% C;C 42%

Conditions, medicines and genes

Notes

From SNPedia

Notes

rs3851179 is a SNP upstream of the PICALM gene. A study of over 5,000 Alzheimer's disease patients (and over 10,000 controls) found a slight protective effect of the (A) allele of this SNP. rs3851179(A) carriers had a slightly decreased risk for Alzheimer's disease, with an odds ratio of 0.85 (CI: 0.8-0.9, p=1.9x10e-8). The association of this SNP and late-onset Alzheimer's disease was replicated over a total of another 1829 cases (and 2576 controls).

Source and license

Adapted from rs3851179 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.