rs241448
A SNP in the TAP2 gene on chromosome 6. Its most notable genotype is G;G: 2.14x increased risk for Alzheimer's
- Gene
- TAP2
- Location
- Chr 632,828,908 (GRCh38)
- Highest magnitude
- 2.1Worth knowing
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
- Minor allele frequency
- 29%
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
- G;GMost notableBad2.14x increased risk for Alzheimer's
- A;GBad1.51x increased risk for Alzheimer's
- A;AGoodcommon
SNPedia records rs241448 on the minus strand: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageG;G 10% A;G 42% A;A 48%
- European ancestry (Utah)G;G 7% A;G 36% A;A 57%
- Han Chinese (Beijing)G;G 16% A;G 45% A;A 39%
- Japanese (Tokyo)G;G 12% A;G 48% A;A 40%
- Yoruba (Nigeria)G;G 7% A;G 33% A;A 60%
- African ancestry (Southwest US)G;G 4% A;G 42% A;A 54%
- Chinese (Denver)G;G 16% A;G 36% A;A 48%
- Gujarati IndianG;G 19% A;G 54% A;A 28%
- Luhya (Kenya)G;G 9% A;G 30% A;A 61%
- Mexican ancestry (Los Angeles)G;G 9% A;G 40% A;A 51%
- Maasai (Kenya)G;G 12% A;G 51% A;A 37%
- TuscanG;G 5% A;G 41% A;A 54%
Related
Conditions, medicines and genes
Notes
From SNPedia
Show notes, about 150 words
While the ApoE4 allele (rs429358(C)) is widely accepted as the predominant genetic risk factor for Alzheimer's disease, there are likely to be numerous other factors, both genetic and environmental, associated to lesser degrees with susceptibility to the disease. Genes influencing the immune system, and in particular susceptibility to viral infections such as herpes, may be among such factors. This SNP, located in the TAP2 gene and thus implicated in the activation of HIV and HSV-1 viruses, is seen more commonly in ~300 Alzheimer patients than in the same number of controls. The risk allele is rs241448(C). The odds ratio is reported to be 2.14 (CI: 1.02-2.55) for rsrs241448(C;C) homozygotes, and 1.51 (CI: 0.80-1.93) for rsrs241448(C;T) heterozygotes, compared with rsrs241448(T;T) homozygotes. This may be particularly significant for carriers of ApoE4 alleles.
Source and license
Adapted from rs241448 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.