rs143332484

A SNP in the LOC105375056 gene on chromosome 6. Its most notable genotype is C;T: Moderate increase (1.67x) in risk for Alzheimer's disease

Gene
LOC105375056
Location
Chr 641,161,469 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CGoodcommon/normalTypical · 0.0
  2. C;TMost notableBadModerate increase (1.67x) in risk for Alzheimer's diseaseWorth knowing · 2.0
  3. T;TBadModerate increase (1.67x) in risk for Alzheimer's diseaseWorth knowing · 2.0

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Conditions, medicines and genes

Other LOC105375056 SNPs

All LOC105375056 SNPs

Notes

From SNPedia

Notes

rs143332484 (p.Arg62His) is a risk variant for Alzheimer's disease found in the TREM2 gene (P = 1.55 × 10-14, OR = 1.67). This gene is highly expressed in microglia which are known to interact with the immune system in AD.

C;T

see rs143332484

T;T

see rs143332484

Source and license

Adapted from rs143332484 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.