rs139709573

A SNP in the TM2D3 gene on chromosome 15. Its most notable genotype is A;G: Possible link to late-onset Alzheimer's, at least in Icelanders

Gene
TM2D3
Location
Chr 15101,646,763 (GRCh38)
Highest magnitude
5.0Very important
Tested on
Not on consumer chips

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;GMost notableBadPossible link to late-onset Alzheimer's, at least in IcelandersVery important · 5.0
  2. G;GGoodcommon/normalTypical · 0.0

On SNPedia: (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Conditions, medicines and genes

Notes

From SNPedia

Notes

rs139709573, also known as Pro155Leu or P155L, is a rare variant in the TM2D3 gene on chromosome 15. At least in Icelanders, although not proven statistically for other Europeans (where it's ten-fold rarer), the rare rs139709573(A) allele was associated with increased risk and earlier onset of late-onset Alzheimer's disease, with an odds ratio of 7.5 (CI:3.5–15.9), p = 6.6x10e-9.dx.doi.org

A;G

see discussion at rs139709573

Source and license

Adapted from rs139709573 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.