rs449647
A SNP in the APOE gene on chromosome 19. Its most notable genotype is T;T: lower levels of ApoE
- Gene
- APOE
- Location
- Chr 1944,905,307 (GRCh38)
- Highest magnitude
- 2.0Worth knowing
- Tested on
- 23andMe
- Minor allele frequency
- 18%
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
- T;TMost notableBadlower levels of ApoE
- A;TBadPossibly lower levels of ApoE
- A;AGoodNormal levels of ApoE
SNPedia records rs449647 on the minus strand: (A;A), (A;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Conditions, medicines and genes
Other APOE SNPs
- rs121918393A;ATwo copies of ApoE3 Christchurch variant (apparently)Very important
- rs121918394A;GHyperlipoproteinemia, type IIIVery important
- rs267606664A;GRare ApoE1 allele; clinical significance unclearVery important
- i5000217C;Tfamilial hyperlipoproteinemia, type IIIImportant
- rs387906567C;TFamilial type 3 hyperlipoproteinemiaImportant
- rs199768005A;TMarked reduced risk of Alzheimer's DiseaseWorth knowing
- rs429358C;Cone of 2 snps relevant to classifying APOE genotypeMinor
- rs7412C;Cpart of APOE4 genoset evaluationMinor
Notes
From SNPedia
Notes
Significant Alzheimer's disease associations with were found for rs449647(A;A) and rs405509(G;G) genotypes (positive), and rs449647(A;T) and rs405509(T;T)
Source and license
Adapted from rs449647 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.