rs616338

A SNP in the ABI3 gene on chromosome 17. Its most notable genotype is T;T: Moderate increase (1.43x) in risk for Alzheimer's disease

Gene
ABI3
Location
Chr 1749,219,935 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
Not on consumer chips

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. T;TMost notableBadModerate increase (1.43x) in risk for Alzheimer's diseaseWorth knowing · 2.0
  2. C;TBadModerate increase (1.43x) in risk for Alzheimer's diseaseWorth knowing · 2.0
  3. C;CGoodcommon/normalTypical · 0.0

SNPedia records rs616338 on the minus strand: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Conditions, medicines and genes

Other ABI3 SNPs

All ABI3 SNPs

Notes

From SNPedia

Notes

rs616338 (p.Ser209Phe) is risk variant in the ABI3 gene reported to be associated with a moderate increase in risk for Alzheimer's disease. (P = 4.56 × 10-10, OR = 1.43). It is involved in immune interaction through microglia.

T;T

see rs616338

C;T

see rs616338

Source and license

Adapted from rs616338 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.